甲状腺癌患者血清TNF-α、IL-17水平与疾病状态及患者生活质量的相关性研究

Correlation between levels of TNF-α and IL-17 in serum and the pathological state and quality of life in patients with thyroid carcinoma

目的探讨甲状腺癌患者血清肿瘤坏死因子-α(TNF-α)和白细胞介素-17(IL-17)水平与疾病病理状态及患者生活质量的关系。方法选取90例甲状腺癌患者,利用酶联免疫吸附方法(ELISA)检测血清TNF-α和IL-17水平,比较不同病理条件下的水平差异。采用肿瘤患者生活质量评分(QOL)标准对患者进行评分,探讨患者TNF-α和IL-17水平与其生活质量及肿瘤预后的关系。结果甲状腺癌淋巴结转移患者TNF-α和IL-17水平均显著增高,二者水平随着TNM分期的增高或细胞分化程度的降低亦均显著升高;患者QOL数值与其血清中TNF-α和IL-17水平均呈负相关;TNM分期、TNF-α和IL-17血清水平是疾病预后不良的独立危险因素。结论甲状腺癌患者血清TNF-α和IL-17水平与其临床病理状态及生活质量密切相关,是该病预后不良的危险因素。

Objective To investigate the relationship between serum tumor necrosis factor-α（TNF-α）and interleukin-17（IL-17）levels and disease pathological status and quality of life in patients with thyroid cancer.Methods Ninety patients with thyroid cancer were enrolled.The levels of serum TNF-αand IL-17 were measured by enzyme-linked immunosorbent assay（ELISA）,and the differences in pathological conditions were compared.Patients were scored using the Quality of Life Score（QOL）criteria for cancer patients to investigate the relationship between TNF-αand IL-17 levels and their quality of life and tumor prognosis.ResultsThe levels of TNF-αand IL-17 in lymph node metastasis of thyroid carcinoma were significantly increased.The levels of TNM and the degree of cell differentiation were significantly increased.The QOL values of patients and their serum TNF-αand IL-17 levels were negatively correlated;TNM stage,TNF-αand IL-17 serum levels were independent risk factors for poor prognosis.Conclusion The levels of serum TNF-αand IL-17 in patients with thyroid cancer are closely related to their clinicopathological status and quality of life,which is a risk factor for poor prognosis of this disease.