肠道微生物对抗肿瘤药物治疗的影响

The influence of gut microbiota on chief treatment strategies with anticancer agents

人体肠道内分布着极其复杂的微生物群,维持着宿主肠道微环境的稳态,参与机体新陈代谢、炎症反应、免疫调控等多项生理过程。肠道微生物通过菌群易位、免疫调控、代谢调节、影响多样性、改变微环境等多种机制,参与肿瘤的发生、发展过程,与抗肿瘤治疗的疗效和不良反应也存在密切的关系。本文梳理了近年来在化疗、靶向治疗、免疫治疗等抗肿瘤药物治疗模式与肠道微生物的关系方面的探讨,并对主要研究进展进行综述。

There exists extremely complex microbiome in the human gut,which maintains the homeostasis of the intestinal microenvironment. Gut microbiota influences the physiological functions of metabolism,inflammation,immunity and other processes systemically. Moreover,gut microbiota is involved in the initiation and progression of tumor,and it is also correlated with the efficacy and toxicity of the treatment with anticancer agents through translocation,immunomodulation,metabolic regulation,reduced diversity,ecological variation and other mechanisms. This review summarized recent evidence on the relationship between gut microbiota and chief treatment strategies with anticancer agents,such as chemotherapy,targeted therapy and immunotherapy.