益生菌对支气管哮喘患儿呼吸力学参数、诱导痰黏附因子及白介素的影响

Effect of probiotics intervention on respiratory mechanical parameters,induced sputum adhesions and interleukin in children with bronchial asthma

目的:观察益生菌干预支气管哮喘(bronchial asthma,BA)患儿的效果,并探讨对患儿呼吸力学参数、诱导痰黏附因子及白介素的影响。方法:选取2013年2月至2015年12月许昌市中心医院收治的92例BA患儿,随机分为两组。对照组给予丙酸氟替卡松吸入气雾剂吸入治疗,孟鲁司特钠片口服,在对照组的基础上,观察组加用枯草杆菌二联活菌颗粒。在治疗前1d及治疗4周后,观察两组患儿的呼吸动力学参数、诱导黏附因子及白介素水平并比较两组的不良反应发生情况。结果:两组患儿治疗后的每千克体质量潮气量、达峰容积比、呼吸峰流速、气道内压、呼吸系统黏滞阻力、平台压、呼吸系统总静态顺应性较治疗前均明显改善,而组间差异无统计学意义(P>0.05);两组患儿治疗后的α_4β_1、α_vβ_6、VCAM-1、ICAM-1、IL-17、IL-33较治疗前均明显降低(P<0.05),且观察组明显低于对照组(P<0.05);在治疗期间,观察组中不良反应发生率为8.70%(4/46),对照组不良反应发生率为10.87%(5/46),差异无统计学意义(X^2=0.123, P>0. 05)。结论:益生菌对支气管哮喘患儿诱导痰黏附因子、白介素的影响较为明显,且安全性较高。

Objective To observe the probiotic intervention effect of children with bronchial asthma （BA）,and to discusses on the respiratory mechanical parameters,induced sputum adhesions and interleukin.Methods A mount of 92 children with BA during February 2013 to December 2015 in Xuchang Central Hospital were selected and randomly divided into two groups. On the basis of conventional treatment,The control group were given inhalation therapy of fluticasone propionate aerosol,and montelukast orally,on the basis of control group,observation group was used medilac-vita.before treatment of 1 d and after treatment of 4 weeks, respiratoy mechanical parameters,induced sputum adhesions and interceukin were observed.and the adverse reactions occur in two groups were compared.Results Tidal volume of per kilogram of body mass,volume ratio of peak and peak value expiration velocity of flow airway pressure,respiratory system viscosity resistance,platform pressure,total static compliance of respiratory system after treatment in two groups were obviously improved compared with before treatment,and without statistically significant difference between groups （ P〉0.05）;α4β1 ,αvβ6,VCAM-1 ,ICAM-1 ,IL-17,IL-33 after treatment in two groups were significantly decreased than before treatment （ P〈0.05）,while that in the observation group after treatment were significantly lower than in the control group （ P〈0.05）; during the period of treatment,the incidence of adverse reactions in observation group was 8.70% （4/46） and control group in the incidence of adverse reactions was 10.87% （5/46）,there was no statistically significant difference （ χ^2=0.123,P〉0.05）.Conclusion The effect of induced sputum adhesions and interleukin in children with bronchial asthma are obvious,and it have high safety.