他克莫司致肾移植受者突发性耳聋1例

Sudden hearing loss in a tacrolimus-treated post-renal transplantation recipient

1例患者肾移植术后规律服用他克莫司(4mg po bid) 4 d后,患者突发单侧右耳耳聋,当天血药浓度为15. 1ng·mL^(-1),医生调整他克莫司剂量,降低患者体内血药浓度到10. 6ng·mL^(-1)后,患者听力恢复正常。考虑突发性耳聋不良反应很可能是由他克莫司导致的。

Apatient presented sudden hearing loss with the unilateral right ear after taking tacrolimus （4 mg po bid） for four days after renal transplantation,and the blood concentration of tacrolimus increased to 15.1 ng·mL^-1 at that time.Doctors adjusted the dose of tacrolimus thus reduced the blood concentration to 10.6 ng·mL^-1 The patient′s hearing recovered then.It is likely that the adverse reaction of sudden hearing loss was caused by tacrolimus.