老年维吾尔族COPD患者茶碱血药浓度监测与分析

Monitoring and analysis of theophylline plasma concentration in elderly Uygur COPD patients

目的通过对2016年9月-2017年9月期间,在喀什地区第一人民医院呼吸科住院的60岁以上服用低浓度茶碱进行治疗的维吾尔族COPD患者,进行血药浓度监测并对结果进行统计分析,为临床合理用药提供参考依据。方法采用均相酶免疫技术检测患者茶碱血药浓度,使用SPSS20.0版统计软件进行数据统计。结果 50例患者口服茶碱100 mg,2次/d,7 d后检测血清茶碱浓度为(3.45±2.0)μg/mL。性别对茶碱浓度没影响(P>0.05),年龄对茶碱浓度有显著影响(P<0.05)。结论根据患者茶碱血药浓度和病情,提供个体化的给药方案能有效的降低茶碱的毒副作用。

Objective Through the period from September 2016 to September 2017,Uighur COPD patients treated with low-concentration theophylline over the age of 60 who were admitted to the respiratory department of the First People＇s Hospital of Kashgar. Conduct blood drug concentration monitoring and statistical analysis of results to provide reference for clinical rational drug use.Method Homogeneous enzyme immunoassay was used to detect theophylline plasma concentrations in patients. Using SPSS20.0 statistical software for data statistics. Result 50 patients were treated with 100 mg of theophylline twice one daily, After 7 days, serum theophylline concentration was（3.45±2.0）μg/mL. Gender had no effect on theophylline concentration（P〉0.05）. Age had a significant effect on the concentration of theophylline（P〈0.05）. Conclusion AAccording to the patient＇s theophylline plasma concentration and condition, providing individualized dosing regimen can effectively reduce the toxic side effects of theophylline.