灯盏花素注射液联合康复功能训练治疗脑卒中的疗效及对病人早期认知障碍的影响

Effect of Breviscapine Injection and Rehabilitation Training on Early Cognitive Impairment in Patients with Stroke

目的探讨灯盏花素注射液联合康复功能训练治疗脑卒中的疗效及对病人早期认知障碍的影响。方法选择2013年11月—2016年11月我院就诊的脑卒中病人150例,采用随机数字表法分为观察组和对照组,各75例。在常规治疗基础上,对照组采用康复功能训练,观察组康复训练联合灯盏花素注射液,连续治疗14 d。比较两组治疗前后美国国立卫生院卒中量表(NIHSS)、Fugl-Meyer运动功能评分法(FMA)、日常生活能力(Barthel指数)、洛文斯顿作业疗法认知成套测试(LOTCA)的变化,并比较临床疗效。结果治疗后,两组NIHSS评分、FAM评分、Barthel指数及LOTCA量表各项指标评分较治疗前均显著改善(P <0.01);观察组NIHSS评分明显低于对照组,FMA评分、Barthel指数均明显高于对照组,差异均有统计学意义(P <0.01);LOTCA量表中,观察组定向力、知觉力、思维操作、注意及专注力、视运动组织力评分均明显高于对照组,差异均有统计学意义(P <0.01);观察组临床疗效总有效率明显高于对照组(90.67%与76.00%,P <0.05)。结论脑卒中病人应用灯盏花素注射液联合康复功能训练治疗,有助于早期改善认知功能障碍,促进神经功能恢复,提高日常生活能力。

Objective To study curative efficacy of breviscapine injection and rehabilitation training in treatment of stroke and its effects on early cognitive impairment.MethodsOne hundred and fifty patients with stroke in our hospital from November 2013 to November 2016 were selected and randomly divided into two groups：control group （n=75）treated with rehabilitation training and treatment group （n=75）treated with breviscapine injection and rehabilitation training in the basis of routine treatment for 14 days.The changes of National Institutes of Health Stroke Scale （NIHSS）,Fugl Meyer Assessment（FMA）scale,ability of daily living （Barthel index） and Loewenstein Occupational Therapy Cognition Assessment（LOTCA）were compared between the two groups before and after treatment,and the clinical efficacy was compared.ResultsAfter treatment,the NIHSS scores,FAM scores,Barthel index,and the score of LOTCA scale in the two groups were significantly improved（P〈0.05）.NIHSS score in the treatment group was lower than that in the control group,and the FMA score and Barthel index were significantly higher than those in the control group（P〈0.05）.The scores of orientation,perception,thinking,attention and concentration,and visual motor in the LOTCA scale in the treatment group were significantly higher than those in the control group（P〈0.05）.The total effective rate of the observation group was significantly higher than that of the control group（90.67% vs 76.00%,P〈0.05）.ConclusionBreviscapine injection and rehabilitation training can improve early cognitive impairment,promote the recovery of nerve function,and improve the ability of daily living in patients with stroke.