挽救性放疗在局部晚期胃癌中的应用作用

Application of salvage radiotherapy in locally advanced gastric cancer

目的探讨挽救性放疗在局部晚期胃癌中的治疗作用。方法选择2012年6月到2016年6月在舞阳县人民医院诊治的局部晚期胃癌患者76例作为研究对象,根据计算机数字法随机分为观察组与对照组,各38例,对照组给予XELOX化疗方案,观察组在对照组治疗的基础上给予挽救性放疗,比较两组患者的近期疗效及不良反应率。结果观察组的治疗有效率为78.9%,高于对照组的47.4%,差异有统计学意义(P<0.05);观察组不良反应发生率(21.05%)与对照组(18.42%)相比,差异无统计学意义(P>0.05)。结论挽救性放疗可能是局部晚期胃癌有效治疗手段,且不增加患者的不良反应,积极的治疗可使一部分患者获益。

Objective To investigate the role of salvage radiotherapy in locally advanced gastric cancer. Methods A total of 76 patients with locally advanced gastric cancer diagnosed and treated in Wuyang People＇s Hospital were selected as the research subjects from June 2012 to June 2016. According to the computer digital method, the patients were randomly divided into the observation group and the control group, with each of 38 cases. The control group was given the XELOX chemotherapy scheme. The observation group was given the salvage radiotherapy on the basis of the control group. The short term effect and the rate of adverse reaction of the two groups were compared. Results The effective rate of treatment in the observation group was （ 78.9% ） higher than that in the control group （ 47.4% ）, and the difference was statistically significant （ P〈 0. 05 ）. The incidence of adverse reactions in the observation group （21.05%） was not statistically significant （P〉0. 05） compared with that in the control group （ 18.42% ）. Conclusions Salvage radiotherapy may be an effective treatment for locally advanced gastric cancer without increasing the adverse reactions of patients. Active treatment can benefit some of these patients.