止哮化痰汤对支气管哮喘急性发作期免疫功能和炎性因子的影响

Effects of Zhixiao Huatan Decoction on Immune Function and Inflammatory Factors in Patients with Acute Attack of Bronchial Asthma

目的观察止哮化痰汤对支气管哮喘急性发作期患者免疫功能和炎性因子的影响,并探讨其作用机制。方法 80例支气管哮喘急性发作期患者随机分为观察组和对照组,每组40例。对照组给予常规治疗,观察组在对照组基础上采用止哮化痰汤治疗,治疗14d后评价2组临床疗效、肺功能、免疫功能和血清炎性因子。结果观察组总有效率为97.50%,明显高于对照组85.00%(P<0.05);治疗后,观察组肺功能和免疫功能各项指标均较治疗前明显改善,且改善程度优于对照组(P<0.05);观察组血清C反应蛋白(CRP)、白介素-8(IL-8)、嗜酸性粒细胞趋化因子(eotaxin)等水平均较治疗前下降,且明显低于对照组(P<0.05)。结论采用止哮化痰汤治疗支气管哮喘急性发作期,疗效显著,能够明显改善患者肺功能、免疫功能和血清炎性因子水平。

Objective To explore the effect and mechanism of Zhixiao Huatan Decoction on immune function and inflammatory factors in patients with acute attack of bronchial asthma. Methods Eighty patients with acute attack of bronchial asthma were randomly divided into observation group and control group,with 40 cases in each group.The control group was given conventional therapy.The observation group was treated with Zhixiao Huatan decoction on the basis of the control group.After 14 days of treatment,the curative effect was evaluated.The changes of lung function,immune function and serum inflammatory factors were observed in both groups. Results The total effective rate in the observation group is significantly higher than the control group（ P〈0.05）.After treatment,the indexes of lung function and immune function in the observation group were significantly improved,and the improvement was better than that of the control group（ P〈0.05）;the levels of inflammatory factors（serum CRP,IL-8 and eotaxin）in the observation group were lower than those before treatment,and the improvement was better than that of the control group（ P〈0.05）. Conclusion The treatment of patients with acute attack of bronchial asthma with Zhixiao Huatan decoction can achieve good curative effect and significantly improve the lung function,immune function and serum inflammatory factors.