230例轻度认知损害患者认知特点与中医证型相关性研究

Correlativity between the Characteristics of aMCI and TCM syndromes in patients of 230 cases

目的通过研究患者认知功能损害特点与各中医证型的相关性,为遗忘型轻度认知功能损害(a MCI)患者的中医辨证诊治提供参考和理论支持。方法对就诊于上海中医药大学附属龙华医院的230例符合a MCI诊断标准的患者进行中医证候辨证分型。结果 1)以肾精亏虚、痰浊阻窍、瘀血阻络证为主,以三证及以上最为多见;2)MMSE总分与肾精亏虚、痰浊阻滞、瘀血阻络证均呈负相关,其中痰浊阻窍证与MMSE相关性最高;肾精亏虚证与Mo CA呈负相关;3)肾精亏虚、痰浊阻窍、肝阳上亢证均与注意和计算能力呈负相关,肾精亏虚证与视空间与执行功能呈负相关,瘀血阻络、肝阳上亢证与命名呈负相关,肾精亏虚证与延迟回忆呈负相关。结论 a MCI的主要证型为肾精亏虚、痰浊阻窍证,MMSE总分与肾精亏虚、痰浊阻滞、瘀血阻络证均呈负相关。

Objective In order to provide reference and theoretical support for the diagnosis and treatment of the patients with mild cognitive impairment（a MCI） in the future, the correlation between the characteristics of cognitive function impairment and the types of TCM syndromes is further deeply excavated. Methods All patients were visited in Longhua Hospital（the Affiliated Hospital of SHUTCM） with Proximal memory loss as its primary symptom. The patients were selected out for TCM Syndrome Differentiation according to the relevant scale. Results 1.The most common are the patients with a MCI with TCM syndrome type distribution to deficiency of kidney-essence, phlegm blocking orifices, blood stasis, complication of three TCM syndrome or more are common, complication of two TCM syndrome is the secondary, patients fit only one TCM syndrome are the least. 2. There are negative correlation between the score of MMSE and deficiency of kidney-essence, phlegm blocking orifices, and blood stasis, phlegm blocking orifices is correlated to MMSE the most while deficiency of kidney-essence is correlated to Mo CA the most. 3. The correlation analyzing between the different TCM Syndrome and Mo CA shows that deficiency of kidney-essence, phlegm blocking orifices, Hyperactivity of liver Yang is negatively correlated to attention and calculation ability. There is negative correlation between deficiency of kidney-essence and visuospatial and executing ability, blood stasis, Hyperactivity of liver Yang is negatively correlated to naming ability. Conclusion Kidney essence deficiency and phlegm and blood stasis is the most common Compound syndrome type; The MMSE and deficiency of kidneyessence, phlegm blocking orifices and blood stasis syndrome were negatively correlated. Phlegm blocking orifices is correlated to MMSE.