单价和五价轮状病毒疫苗保护效果的Meta分析

Meta-analysis of protective efficacy of the monovalent and the pentavalent rotavirus vaccines

目的 评价两种主流轮状病毒疫苗Rotarix和RotaTeq对重症轮状病毒胃肠炎和任意严重程度轮状病毒胃肠炎的流行病学保护效果.方法 检索2006年1月至2017年10月公开发表的有关这两种疫苗流行病学保护效果的随机对照试验文献,采用RevMan 5.3软件和STATA 11.0软件进行Meta分析.结果 共纳入12篇文献,总研究对象为53 573人.对于重症轮状病毒胃肠炎,汇总的保护效果为85％（95％CI：74％～92％）;在发达国家或地区汇总的保护效果为92％（95％CI：88％～94％）;在中国广西的汇总保护效果为75％ （95％CI：63％～83％）.对于任何严重程度的轮状病毒胃肠炎,汇总的保护效果为67％（95％CI：53％～77％）,在发达国家或地区的汇总保护效果为76％（95％CI：72％～80％）;在中国广西的汇总保护效果为64％（95％CI：54％～72％）.结论 这两种轮状病毒疫苗都能有效预防重症轮状病毒胃肠炎的发生,对任意严重程度轮状病毒胃肠炎也有较好的保护效果.

Objective To evaluate the vaccine protective efficacy （VE） of two mainstream rotavirus vaccines,Rotarix and RotaTeq,against severe rotavirus gastroenteritis （SRVGE） and any-severity rotavirus gastroenteritis （any-severity RVGE）.Methods Literatures of the randomized controlled trial （RCT） studies on VE for the two kinds of rotavirus vaccine were retrieved in the period of January 2006 to October 2017.RevMan 5.3 and STATA 11.0 software were employed to manipulate the pooled data of included literatures.Results A total of 12 RCT studies and 53 573 subject were included.The pooled VE against SRVGE was 85％ （95％CI：74％-92％）.In developed countries or regions,the pooled VE against SRVGE was 92％ （95％CI：88％-94％）.In Guangxi,China,the value reached 75％ （95％CI：63％-83％）.The pooled VE against any-severity RVGE was 67％ （95％CI：53％-77％）.In developed countries or regions,the pooled VE against any-severity achieved 76％ （95％CI：72％-80％） and that in Guangxi Autonomous Region,China was 64％ （95％CI：54％-72％）.Conclusions Both rotavirus vaccines can provide effective protection against SRVGE and protective effect against any-severity RVGE.