环烯醚萜类化合物治疗氧化应激诱发疾病的研究进展

Research Progress of Iridoid Compounds in the Treatment of Oxidative Stress-Induced Diseases

目的:综述环烯醚萜类化合物对氧化应激诱发的相关疾病可能的治疗机理。方法:查阅、总结国内外发表的氧化应激诱导的相关疾病的成因和环烯醚萜化合物调节相关疾病的可能机理的报道。结果:氧化应激可以引起广泛的细胞内损伤,从而诱发神经系统疾病、肿瘤和糖尿病等相关疾病。环烯醚萜类化合物可通过调节机体抗氧化应激的能力,预防和减缓相关疾病的发生和发展。结论:环烯醚萜类化合物降低机体氧化应激水平,对于开发此类化合物的新药具有广泛前景。

Objective： To review the possible therapeutic mechanisms of iridoid compounds in the treatment of oxidative stress-induced diseases. Methods： The literatures on the causes of oxidative stress-induced diseases and the possible mechanisms of regulation of the diseases by iridoid compounds published at home and abroad were reviewed. Results： Oxidative stress can cause a wide range of intracellular damages which can induce nervous system diseases, tumors and diabetes, etc.. Iridoid compound could prevent and alleviate the occurrence and development of related diseases by regulating the ability to resist the oxidative stress. Conclusion： Iridoid compounds could reduce the level of oxidative stress and have promising prospects in the development of new drugs.