原虫感染对宿主免疫应答的影响

Influence of protozoan parasite infection on host immune response

原虫感染可引起严重的肠道黏膜免疫应答,其侵入机体时,会触发机体的固有免疫应答和适应性免疫系统反应,包括诱导特异性抗体的产生以及效应T淋巴细胞的形成。T淋巴细胞包括CD4＋和CD8＋两大类,CD4＋为辅助性T淋巴细胞,通过膜表面分子及其所分泌的细胞因子辅助并调控B淋巴细胞和巨噬细胞的活化与功能;CD_8~＋是杀伤细胞,也是肠道上皮细胞主要表达因子,功能与自然杀伤细胞相似,可以与被感染上皮细胞接触将其杀死。B淋巴细胞主要功能是制备抗原特异性抗体,发挥体液免疫作用。文章将从两方面论述原虫与机体免疫应答之间的相互调节作用。

Abstract：Protozoan parasite infection can cause severe intestinal mucosal immune response. When the parasite invades the body, it can trigger the innate immune response and adaptive immune system response, including production of specific antibodies and the formation of effector T lymphocytes.T-cell was divided into two groups： CD＋4 and CD＋8. CD＋4 T-cell is an anxihary T lymphocyte, which can regulate the activation and function of B lymphocytes and macrophages through membrane surface molecules and cytokines secreted by them.CD~ T-cell is a killer cell and a major expression factor in intestinal epithelial cells.Its function is similar to that of natural killer cells, which can kill infected epithelial cells through contact with the cells.The main function of B-cell is to prepare antigen specific antibody, and play the humoral immune function. This article will discuss the interaction between protozoan and organism immune response from two aspects.