金属蛋白酶组织抑制剂-2联合胰岛素样生长因子结合蛋白-7对于急性肾损伤早期诊断及预后评估的临床意义

Tissue inhibitor of metalloproteinases-2 binding with insulin-like growth factor binding protein-7 in early diagnosis and prognostic evaluation of acute kidney injury

急性肾损伤(AKI)是重症患者常见的临床综合征,早期诊断可显著降低患者病死率。血肌酐和尿量作为传统诊断指标存在滞后性,近年来研究发现的一批新型生物标志物中,联合应用表达于肾小管细胞的与细胞损伤相关的细胞周期标志物金属蛋白酶组织抑制剂-2(TIMP-2)与胰岛素样生长因子结合蛋白-7(IGFBP-7)早期预测AKI的发生风险并对患者预后进行早期评估。本文将主要叙述细胞周期标志物TIMP-2和IGFBP-7用于AKI早期诊断及预后评估的相关内容。

Acute kidney injury is a common clinical syndrome in critically ill patients. Although early diagnosis could decrease mortality significantly, traditional diagnosis biomarkers such as serum creatinine and urine output usually lag. In recent years numbers of novel biomarkers have been found. As cell cycle biomarkers related to cell injury expressed on renal tubular cell, tissue inhibitor of metalloproteinases-2（TIMP-2） binding with insulin-like growth factor binding protein-7（IGFBP-7） could be used in early diagnosis and prognostic evaluation of AKI.