右美托咪定对结直肠癌手术后患者早期认知功能障碍的预防效果观察

Preventive effect of Dexmedetomidine on early cognitive impairment in patients with colorectal cancer surgery

目的探讨右美托咪定对结直肠癌手术后患者早期认知功能障碍的预防效果。方法选择2016年8月—2018年8月期间收治的结直肠癌手术患者76例,随机分为观察组与对照组,每组各38例。观察组麻醉诱导前静注右美托咪定,对照组注射等量生理盐水,术中静注异丙酚复合瑞芬太尼。比较2组患者术前1 d和术后第1,3天简明智能状态量表(MMSE)评分。结果观察组术后第1天、第3天MMSE评分均明显高于对照组,差异有统计学意义(P<0.05)。结论结直肠癌手术患者在麻醉诱导前应用右美托咪定,能够明显提升术后认知功能,对早期POCD有良好的预防效果,值得推广运用。

Objective To investigate the preventive effect of dexmedetomidin on early cognitive impairment in patients with colorectal cancer. Methods 76 patients with colorectal cancer surgery from Aμgust 2016 to Aμgust 2018 were randomly divided into the observation group and the control group,38 cases in each group. In the observation group,dexmedetomidine was injected before anesthesia induction,and the control group was treated with saline instead of right metoimidin,and propofol combined with remifentanil during the operation. The MMSE score was compared between first days before operation and first,third days after operation. Results The score of MMSE in the observation group was significantly higher than that of the control group on first days and third days after the operation,and the difference was statistically significant（P〈0.05）.Conclusion Dexmedetomidine can significantly improve postoperative cognitive function in patients with colorectal cancer before induction of anesthesia,and has good preventive effect on early POCD.It is worthy of popularization and application.