急性心肌梗死伴消化道出血的治疗方法探讨

Treatment of Acute Myocardial Infarction With Gastrointestinal Bleeding

目的观察泮托拉唑钠肠溶胶囊联合硫酸氢氯吡格雷片治疗急性心肌梗死伴消化道出血的临床疗效。方法选取2015年1月—2017年1月收治的104例急性心肌梗死伴消化道出血患者作为研究对象。将其随机分为两组,每组各52例。常规组予以埃索美拉唑肠溶胶囊和硫酸氢氯吡格雷片的联合口服治疗,实验组予以泮托拉唑钠肠溶胶囊和硫酸氢氯吡格雷片的联合口服治疗,对比两组治疗总有效率、不良反应发生率。结果治疗后,实验组的治疗总有效率高于常规组,差异具有统计学意义(P<0.05)。常规组和实验组患者的不良反应发生率对比,差异无统计学意义(P>0.05)。结论对急性心肌梗死伴消化道出血患者予以泮托拉唑钠肠溶胶囊和硫酸氢氯吡格雷片的联合治疗,疗效显著,不良反应较小。

Objective To observe the clinical efficacy of pantoprazole sodium enteric capsules combined clopidogrel hydrogen sulphate tablets in the treatment of acute myocardial infarction associated with gastrointestinal bleeding. Methods 104 patients with acute myocardial infarction with gastrointestinal bleeding were selected from January 2015 to January 2017. They were randomly divided into two groups, 52 cases in each group. The routine group was given the combined oral treatment of esomeprazole enteric capsule and hydroclopidogrel sulfate tablets, and the experimental group was treated with pam Tora sodium enteric capsule and hydroclopidogrel sulfate tablet. The total efective rate of the two groups was compared. Incidence of adverse reactions. Results After treatment, the total effective rate of the experimental group was higher than that of the conventional group, and the difference was statistically signifcant （P 〈 0.05）.There was no signifcant diference in the incidence of adverse reactions between the conventional group and the experimental group （P 〉 0.05）.Conclusion Pantoprazole sodium enteric-coated capsules and clopidogrel bisulfate tablets are effective in the treatment of acute myocardial infarction with gastrointestinal bleeding.