抗生素治疗恙虫病合并多脏器衰竭的疗效观察

Effect of Antibiotic Treatment on Tsutsugamushi Disease Complicated With Multiple Organ Failure

目的分析多西环素、氯霉素、阿奇霉素治疗恙虫病合并多脏器功能衰竭的疗效。方法研究阶段为2015年1月—2017年12月,共纳入研究对象165例,均为羌虫病合并多脏器功能衰竭患者,随机分为A组、B组、C组,A组采用多西环素,B组采用氯霉素,C组采用阿奇霉素,对比三组临床疗效等指标。结果 A组痊愈率100%,B组痊愈率100%,C组痊愈率100%,三组差异无统计学意义,P>0.05。三组体温恢复正常时间、焦痂脱落时间、住院时间差异无统计学意义,P>0.05。A组与B组不良反应发生率差异无统计学意义,P>0.05,A组、B组不良反应发生率明显高于C组,差异有统计学意义,P<0.05。结论针对羌虫病合并多脏器功能衰竭采用阿奇霉素治疗,不良反应发生更少,在临床应用效果明显。

Objective To analyze the efficacy of doxycycline,chloramphenicol and azithromycin in treating tsutsugamushi disease with multiple organ failure. Methods From January 2015 to December 2017, 165 patients with tsutsugamushi disease complicated with multiple organ failure were enrolled in the study. They were randomly divided into group A, group B and group C, group A were treated with doxycycline B, group B was treated with chloramphenicol and group C was treated with azithromycin,and the clinical efficacy was compared among the three groups. Results The cure rate was 100% in group A, 100% in group B and 100% in group C. There was no significant difference among the three groups（P〉 0.05）. There was no significant difference in the recovery time of body temperature, eschar shedding time and hospitalization time among the three groups（P 〉 0.05）. There was no significant difference in the incidence of adverse reactions between group A and group B（P 〉 0.05）. The incidence of adverse reactions in group A and group B was significantly higher than that in group C, and the difference was statistically significant（P 〈 0.05）.Conclusion Azithromycin has less adverse reactions in the treatment of tsutsugamushi disease complicated with multiple organ failure and has obvious clinical effect.