糖皮质激素联合血浆置换治疗三氯乙烯药疹样皮炎的疗效及对炎性因子的影响

Clinical effect of glucocorticoids combined with plasma exchange on trichloroethylene induced medicamentosa-like dermatitis and its influence on inflammatory factors

目的:探讨糖皮质激素联合血浆置换在三氯乙烯药疹样皮炎治疗中的临床价值。方法:选取2014年1月至2017年10月收治的64例三氯乙烯药疹样皮炎患者为研究对象,随机分为对照组和观察组,每组各32例。对照组给予糖皮质激素治疗,观察组在对照组基础上联合血浆置换治疗,观察两组治疗效果及炎性因子变化情况。结果:观察组治疗总有效率为100.00%高于对照组的87.50%,两组比较差异有统计学意义(P<0.05);炎性因子水平两组治疗前比较差异无统计学意义(P>0.05),治疗后观察组γ-干扰素(IFN-γ)、肿瘤坏死因子-α(TNF-α)水平较对照组低(P<0.05)。结论:糖皮质激素联合血浆置换治疗三氯乙烯药疹样皮炎,效果确切,且能有效降低炎性因子水平,值得推广。

Objective ：To probe into the clinical values of glucocorticoids combined with plasma exchange in the treatment of trichloroethylene induced medicamen- rosa- like dermatitis. Methods ：64 patients with trichloroethylene induced medicamentosa- like dermatitis hospitalized from January 2014 to October 2017 were cho- sen and randomly divided into the control group and the observation group, with 32 patients in each group. The control group were treated with glucocorticoid while the observation group were treated with plasma exchange on the basis of the treatment used in the control group, with the therapeutic effect.s and inflammatory factors of the two groups observed. Results：The total effective rate in the observation group was 100%, significantly higher than that in the control group （ 87.50 % ）, the differ- ence being statistically significant （ P 〈0.05） ; There was no significant difference in the levels of inflammatory factors between the two groups before treatment （ P 〉 0.05）. After the treatment , the interferon -7 （IFN -7 ） and tumor necrosis factor- alpha （TNF -α） in the observation group were significantly lower than those in the control group, the difference being statistically significant （ P 〈 0.05 ）. Conclusion ： Glucocorticoids combined with plasma exchange is effective in the treatment of trlchloroethylene induced medicamentosa - like dermatitis and can effectively reduce the level of inflammatory factors, worthy of promotion.