绒毛膜羊膜炎与未足月胎膜早破后早产儿神经系统损伤的相关性

Relationship between chorioamnionitis and nervous system injury in preterm infants after preterm premature rupture of membranes

目的:探讨绒毛膜羊膜炎与未足月胎膜早破后早产儿神经系统损伤的相关性。方法:选取63例未足月胎膜早破合并绒毛膜羊膜炎患者作为观察组,选取同期收治的63例未足月胎膜早破未合并绒毛膜羊膜炎患者作为对照组,比较两组患者神经系统损伤发生率、血清C反应蛋白(Commercial Rent Planning,CRP)、白细胞介素6(interleukin 6,IL-6)水平。结果:观察组患者CRP(136.67±41.34)ng/m L、IL-6(188.56±26.39)ng/m L水平高于对照组的(84.23±21.56)ng/m L、(121.56±27.49)ng/m L(P<0.05);随着绒毛膜羊膜炎疾病越严重,早产儿神经系统损伤越严重,两者呈现正相关(r=0.627,P=0.018)。结论:绒毛膜羊膜炎与未足月胎膜早破后早产儿神经系统损伤成正相关,同时可通过检测CRP、IL-6水平提高绒毛膜羊膜炎的诊断率,及早采取针对性措施,改善围生儿结局。

Objective：To investigate the relationship between chorioanmionitis and nervous system injury in premature infants after preterm pre- mature rupture of membranes. Methods：The clinical data of 63 patients with preterm premature rupture of membranes and chorioanmionitis were selected as the observation group. At the same time, the clinical data of 63 cases of non full - term premature rupture of membranes with chorioam- nionitis were selected as the control group. The incidence of nervous system injury, serum Commercial Rent Planning （CRP） and interleukin 6 （ IL -6） levels were compared between the two groups. Results：The levels of CRP （136.67 ± 41.34） and IL- 6 （188.56 ± 26.39） in the observa- tion group were significantly higher than those in the control group （84.23 ± 21.56, 121.56 ± 27.49） （ P 〈 0.05 ）. The more severe the chorio- amnionitis was, the more serious the nervous system injury in premature infants was, and there was a positive correlation between them （ r= 0. 627, P = 0. 018 ）. Conclusion： Chorioanmionitis is positively related to the nervous system injury in preterm infants with preterm premature rupture of the membranes, and can improve the diagnostic rate of chorionic amnionitis by detecting CRP and IL - 6 levels, and take early targeted measures to improve the perinatal outcome.