慢性乙肝患者甲状腺参数与疾病程度的相关性

Correlation between thyroid parameters and disease severity in patients with chronic hepatitis B

目的:探讨慢性乙肝患者甲状腺参数与疾病程度的相关性。方法:将109例慢性乙肝患者作为观察组,选取同期健康体检的109例人群作为对照组,均检测促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、总三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)、游离甲状腺素(FT4),比较两组的甲状腺参数及与疾病程度的相关性。结果:观察组的FT3、TT3、TT4、FT4水平低于对照组(P<0.05),重度慢性乙肝患者的各项甲状腺参数均低于轻度与中度慢性乙肝,与疾病程度呈现正相关(P<0.05)。结论:甲状腺参数可反映慢性乙肝患者疾病程度,可作为慢性乙肝患者疾病发展及预后的重要评估指标。

Objective：To explore the correlation between thyroid parameters and disease severity in patients with chronic hepatitis B. Meth- ods ： 109 patients with chronic hepatitis B were selected as the observation group and 109 healthy people during the same period were selected as the control group. The thyroid stimulating hormone （TSH）, free three iodine thyroxine （FT3）, total three iodine thyroxine （TT3）, total thyroxine （ TT4）, free thyroxine （FT4） of the two groups were detected. The correlation between thyroid parameters and disease severity was compared in the two groups. Results：The levels of FT3, TT3, TT4 and FT4 in the observation group were significantly lower than those in the control group（ P 〈 0.05 ）. The thyroid parameters of patients with severe chronic hepatitis B were all lower than those of mild and moderat 李彩红 e patients, which have a positive correlation with disease severity（ P 〈 0.05）. Conclusion：Thyroid parameters can reflect the disease severity in patients with chro- nic hepatitis B, and can be used as an important indicator of disease and prognosis.