外泌体对肿瘤发生发展影响的研究进展

Research progress on the effect of exocrine on tumor development

目的 外泌体是一种直径在30～120 nm的胞外囊泡。肿瘤外泌体携带的蛋白、脂类、核酸等恶变信息,能使受体细胞重构。外泌体已经成为一种公认的生物介质,参与到肿瘤发生发展的大多数过程,其与肿瘤增殖、微环境的重构、肿瘤转移以及靶向治疗有着密切相关,文章就外泌体对肿瘤发生发展的影响进行综述。

Exosomes are small membrane vesicles with a size ranging from 30 to 120 nm. Cancer exosomes carry malignant information in the form of proteins,lipids,and nucleic acids that can reprogram recipient cells. Exosomes have emerged as putative biological mediators in cancer contributing to major steps of disease progression,and it has closely relations with the various steps of tumor proliferation,microenvironment reprogramming,tumor metastasis and targeted therapy.