睡眠质量与糖尿病前期患者临床转归的相关性研究

Study on thecorrelation of clinical outcome of pre-diabetes patients with sleep quality

目的探讨睡眠质量对糖尿病前期患者3年后的临床转归情况,为糖尿病的防治提供理论依据。方法随机抽取四川泸州居民健康体检者3 847人,从中筛选出糖尿病前期患者947例,并对其进行3年后的随访。结果3年后随访发现,转归为正常糖耐量174人、空腹血糖受损(IFG)37人、糖耐量异常(IGT)245人、(IFG+IGT)76人、糖尿病297人,转归之间的差异有统计学意义(P<0.001)。Logistic回归分析显示:空腹血糖、睡眠质量、年龄、糖化血红蛋白、胆固醇均是糖尿病前期患者转归为糖尿病的危险因素。与睡眠质量好组相比,睡眠质量差与糖尿病前期转归的危险度更相关(P<0.001)。结论在糖尿病前期阶段,睡眠质量差使其转归为糖尿病的风险增加,睡眠质量好与糖尿病转归风险降低相关。

Objective To study the association of sleep quality and outcome of pre diabetes and to provide evi dence for theprevention and control of diabetes. Methods A total of 947 patients with pre diabetes were recruited from an investigation of the residents health status of luzhou with multi stage stratified random sampling. Results Af ter a median follow up of three years,the numbers of patients who had an outcome of normal sugar tolerance, IFG, IGT, IFG@ IGT and diabetes were174,37,245,76 and 297. The three groups were significantly different in outcome （P^0. 001）. The correlation between sleep quality and incident diabetes in pre diabetes was analyzed with logistic. The correlation between in poor sleep quality and incident diabetes in pre diabetes was analyzed with logisticregres sion analysis, subjects in good sleep quality group lower risk of developing incident diabetes in crude model than those in poor sleep quality. Conclusion In pre diabetes, in poor sleep quality is associated with an increased risk of incident diabetes, good sleep quality is associated with a lower risk of incident diabetes.