临床药师对先天性心脏病封堵术患者使用抗菌药物的干预

Effects evaluation of clinical pharmacists intervention on prophylactic use of antibiotics during perioperative closure of congenital heart disease

目的评价临床药师干预对先天性心脏病封堵术患者预防使用抗菌药物的影响。方法采用回顾性调查方法,选取行先天性心脏病封堵术的患者,385例为干预前组(2016年1~5月),390例为干预后组(2017年1~5月)。比较临床药师干预前后2组患者预防使用抗菌药物的情况。结果干预后,患者围术期预防用抗菌药物选择合理率从35.3%提高到87.4%,给药时机合理率从55.6%提高到97.9%,给药疗程合理率从74.1%提高到93.1%,差异有统计学意义;且患者平均住院药物费用和抗菌药物费用与干预前相比明显降低(P<0.05)。结论临床药师干预对先天性心脏病封堵术围术期抗菌药物的合理使用起到积极的作用。

Objective To investigate the effects of clinical pharmacists intervention on prophylactic use of antibiotics in perioperative closure of congenital heart disease. Methods The 385 patients with congenital heart disease occlusion in our hospital from January to May in 2016 （before intervention） and the 390 patients from January to May in 2017 （after intervention） were randomly collected.The prophylactic use of antimicrobials was compared between the 2 groups before and after the intervention. Results After intervention,the qualified rate of perioperative antibiotics selection in perioperative period was increased from 35.3% to 87.4%,the qualified rate of appropriate time of antibiotic was increased from 55.6% to 97.9%,the qualified rate of continued treatment time was increased from 74.1% to 93.1%,and there was significant difference.The average hospitalization expense and antibacterial cost of the patients were significantly lower than those before intervention （P〈0.05）. Conclusion Clinical pharmacists′ intervention could improve the rational use of antibacterial during perioperative period of congenital heart disease.