离子型谷氨酸受体在长时程增强产生机制中的研究进展

The research progress of ionic glutamate receptor in the mechanism of long-time potentiation

长时程增强(Long-term potentiation,LTP)是一种发生在神经细胞信号传输中持久的增强现象。在分子水平研究学习和记忆能力,反应海马功能可塑性的长时程增强是常用的指标,其作用的改变与学习记忆密切相关。长时程增强增加会促进学习记忆能力,而长时程增强减弱会导致学习记忆能力的下降。诱导长时程增强发生的相关机制非常复杂,迄今尚未完全阐明,而关于离子型谷氨酸受体在其中的作用研究相对较少。因此,本文对离子型谷氨酸受体在长时程增强形成条件、分子机制等方面进行了综述。

Long-term potentiation（LTP）is a persistent enhancement in signal transmission of nerve cells.At the molecular level,the study and memory ability of the hippocampal function plasticity is a commonly used indicatorand the change of its function is closely related to learning and memory.Increased long-term potentiation will promote learning and memory,and weakened long-term potentiation will lead to a decline in learning and memory.The mechanisms involved in inducing long-term potentiation are very complex and have not yet been fully elucidated,and there are relatively few studies on the role of ionic glutamate receptors.Therefore,this paper reviews the formation conditions and molecular mechanisms of ionic glutamate receptors in the long term.