自身免疫性肝病相关性风湿病样及皮肤表现

Rheumatic and skin manifestations associated with autoimmune liver diseases

自身免疫性肝病主要包括自身免疫性肝炎、原发性胆汁性胆管炎、原发性硬化性胆管炎及各种类型的重叠综合征,常与肝外自身免疫性疾病相关。但自身免疫性肝病与风湿性疾病和(或)皮肤病的相关性描述甚少。为此,详尽综述了与自身免疫性肝病相关的风湿病样及皮肤表现,以及一些非特异性抗体的临床意义。对并发风湿性疾病和(或)皮肤病的患者治疗应个体化。

Autoimmune liver diseases mainly include autoimmune hepatitis,primary biliary cholangitis,primary sclerosing cholangitis,and various types of overlap syndromes and are often associated with extrahepatic autoimmune diseases. However,few studies have described the association of autoimmune liver diseases with rheumatic disease and/or skin disease. For this purpose,this article reviews the rheumatic and skin manifestations associated with autoimmune liver diseases in detail and the clinical significance of non-specific antibodies. It is pointed out that individualized treatment should be given to patients with rheumatic disease and/or skin disease.