45岁以上固定大量献血者铁蛋白及血红蛋白水平调查

Investigation of ferritin and hemoglobin in regular voluntary donors of 45 years old and above with large number donation

目的:了解青岛地区45岁以上固定大量无偿献血者铁蛋白(FER)、血红蛋白(HGB)等检测情况,评估固定大量无偿献血对献血者铁代谢及血红蛋白等健康指标的影响,为无偿献血招募宣传策略提供科学依据。方法:招募2006—2016年青岛地区45~65岁固定大量无偿献血者,采集空腹静脉血,检测指标:FER、HGB、红细胞计数(RBC)、血细胞比容(HCT)、平均红细胞体积(MCV)。从某三级甲等医院查体中心随机抽取45~65岁未献过血志愿者作为对照,按不同年龄段及性别分组,进行统计学分析。结果:(1)45~54岁男性大量献血者的FER显著低于未献血组(P<0.01),HCT低于未献血组(P<0.05),RBC、HGB、MCV与对照组比较差异无统计学意义(P>0.05)。(2)55~65岁男性大量献血者FER低于同年龄未献血组(P<0.05),HGB、RBC、HCT、MCV与对照组比较差异无统计学意义(P>0.05)。(3)45~50岁女性献血者的FER、RBC、HGB、HCT、MCV与对照组比较均差异无统计学意义(P>0.05)。(4)51~65岁女性献血者的FER低于未献血组(P<0.05),HGB、MCV高于未献血组(P<0.05),RBC、HCT与未献血组比较差异无统计学意义(P>0.05)。(5)男性大量献血者FER与献血量之间呈显著负相关(P<0.01);HGB与献血量之间呈负相关,P<0.05,HCT与献血量之间呈显著负相关,(P<0.01),而RBC及MCV与献血量之间无相关性(P>0.05);女性大量献血者FER、RBC、HGB、HCT、MCV与献血量之间无相关性(P>0.05)。(6)男性大量献血者,FER高于正常范围的例数与不献血组比较有统计学差异(P<0.01)。而女性大量献血者,FER高于正常范围的例数与不献血组比较差异无统计学意义(P>0.05)。结论:45岁以上男性长期大量献血FER低于不献血人群,但未引起HGB、RBC、MCV的降低,FER的降低与献血量相关;FER高于正常比例少于不献血组。45~50岁女性大量献血者未见FER、RBC、HGB、HCT、MCV的降低,而51~65岁女性献血者的FER低于未献血组。针对不同性别、年龄的大量献血者应采取不同的招募措施和延伸服务。

Objective：To investigate the ferritin and hemoglobin status of regular voluntary donors with large number donation,assessment their ferritin and hemoglobin status,and provide evidence for the scientific implement of blood donation.Method：Recruitment from 2006 to 2016 in Qingdao area regular voluntary donors of 45-65 years with large number donation,fasting venous blood samples were drawn for ferritin（FER）,red blood cell count（RBC）,hemoglobin（HGB）,hematocrit（HCT）,mean corpuscular volume（MCV）.We had statistical analysis according to age and gender groups.45 to 65 years old volunteers were randomly selected from the examination center of a top three hospital in the city as a control.Result：（1）For male donors of 45-54 years old,FER was significantly lower than that of non-blood donation group（P0.01）,HCT was lower（P0.05）,but RBC,HGB and MCV had no significant difference with control group（P0.05）.（2）For male donors of 55-65 years old,FER was lower than that of control group（P0.05）,but HGB,RBC,HCT and MCV had no significant difference with control group（P0.05）.（3）For 45 to 50 years old female donors,FER,HCT,RBC,HGB and MCV had no significant difference with control group（P0.05）.（4）For 51 to 65 years old female donors,FER was lower than that of control group（P0.05）,HGB and MCV were higher（P0.05）,but HCT and RBC had no significant difference with control group（P0.05）.（5）For male donors,there was a negative correlation between FER,HCT and blood donation（P0.01）,and there was a significant negative correlation between HGB and blood donation（P0.05）.For female there were no negative correlation between FER,HGB,HCT and blood donation（P0.05）.（6）For male donors,higher FER cases were significantly different from control group（P0.05）.But for female,higher FER cases were not different from control group（P0.05）.Conclusion：Male donors＇ FER,with long-term massive donation of blood over 45 years old,was lower than that of non-blood vonlenteers,but it did not cause a decrease in HGB,RBC and MCV.The decrease in FER was related to blood donation.And higher FER cases were significantly less than control group.Among female blood donors aged 45-50 years there were no reductions in FER,RBC,HGB,HCT and MCV.The FER of female blood donors aged 51-65 years was lower than that of the non-blood donor group.For different gender and age blood donors,different recruitment measures and extension services should be taken.