摘要
A growing number of studies show that drug and non-drug means can be activated phosphatidyl inositol-3-kinase serine/threonine kinase(PI3K/Akt signaling pathway) in the beginning of reperfusion,and make its downstream fork protein transcription factor O3a(FoxO3a) phosphorylation,and then promote cell survival and reduce the apoptosis so as to alleviate the symptoms of myocardial ischemia.In this paper,the role of PI3K/Akt and FoxO3a effector in myocardial ischemia was reviewed,and illustrated the role of PI3K/Akt/FoxO3a signaling pathway in myocardial ischemia.
A growing number of studies show that drug and non-drug means can be activated phosphatidyl inositol-3-kinase serine/threonine kinase（PI3K/Akt signaling pathway） in the beginning of reperfusion,and make its downstream fork protein transcription factor O3a（FoxO3a） phosphorylation,and then promote cell survival and reduce the apoptosis so as to alleviate the symptoms of myocardial ischemia.In this paper,the role of PI3K/Akt and FoxO3a effector in myocardial ischemia was reviewed,and illustrated the role of PI3K/Akt/FoxO3a signaling pathway in myocardial ischemia.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2018年第4期300-300,共1页
Chinese Journal of Pharmacology and Toxicology
基金
supported by Inner Mongolia Natural Science Foundation(2017MS0845)
Inner Mongolia Autonomous Region Science and Technology Innovation Guide Reward Fund(02039003)
