Molecular Mechanism of Aconite-Ginger Muscle against Myocardial Ischemia Injury Based on Network Pharmacology

OBJECTIVE To use network pharmacology to predict and analyze the mechanism of Aconite-Ginger against myocardial ischemia.METHODS TCMSP was used to collect the active compounds of Aconite-Ginger and predict the targets of active compounds.At the same time,target sites of anti-myocardial ischemic injury drugs were collected using DisGeNET and CTD database,and then active compounds and target sites were compared.Analyze and screen out the targets of AconiteGinger anti-cardiac machine ischemia.GO,KEGG analysis and Aconite-Ginger drug molecule-target were performed on selected targets using MAS 3.0 and Cytoscape 3.3.0 software.RESULTS 27 common targets of Aconite-Ginger anti-ischemia ischemia and 63 signal pathways were predicted.CONCLUSION Aconite-Ginger mainly regulates calcium signal transduction,apoptosis and MAPK signaling pathway,which can also regulate through toll-like receptors,Fc epsilon RI and other signal pathways,so it is speculated that it may participate in regulation Apoptosis,inflammatory response,enhancement of myocardial function,etc.,thereby exerting an anti-ischemic effect.It laid a good foundation for further revealing its mechanism of action.