枳实导滞汤治疗便秘型肠易激综合征(肠道湿热)随机平行对照研究

Randomized Parallel Controlled Study on the Treatment of Constipation Irritable Bowel Syndrome(Changdao Shire/肠道湿热) with Zhishi Daozhi Decoction(枳实导滞汤)

[目的]观察枳实导滞汤治疗便秘型肠易激综合征(肠道湿热)疗效。[方法]使用随机平行对照方法,将60例门诊患者按就诊顺序号简单随机分为两组。对照组30例曲美布汀,2粒/次,3次/d,餐前服用。治疗组30例枳实导滞汤(大黄15g,枳实、神曲各12g、茯苓9g,黄芩、黄连各12g,白术9g,泽泻6g,木香12g,甘草生6g),泻下即止,改大黄为3g,加川楝子12g,鸡矢藤15g,1剂/d,水煎150mL,分两次温服。连续治疗1周为1疗程。观测临床症状、腹胀、腹痛、排便、不良反应。连续治疗3疗程(3周),判定疗效。[结果]治疗组痊愈9例,显效10例,有效9例,无效2例,总有效率93.33%;对照组痊愈3例,显效9例,有效10例,无效8例,总有效率73.33%;治疗组疗效优于对照组(P<0.05)。症状积分两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]枳实导滞汤治疗便秘型肠易激综合征(肠道湿热),疗效满意,无严重不良反应,值得推广。

[Objective] To observe the curative effect of Zhishi Daozhi decoction in treating constipation irritable bowel syndrome （Changdao Shire）. [Methods] 60 patients were randomly divided into two groups by random parallel control method. Control group 30 cases of trimebutine, 2 tablets/times, 3 times/d, before meals. In the treatment group, 30 cases of Zhishi Daozhi decoction （Dahuang 15g, Zhishi, Shenqu each 12g, Fuling 9g, Huangqin, Huanglian each 12g, Baizhu 9g, Zexie 6g, Muxiang 12g, Shenggancao 6g）, Stop diarrhoea, Dahuang changed to 3g, add Chuanlianzi 12g, Jixueteng 15g, 1 doses/d, and decocted water two times. Continuous treatment for 1 weeks was the 1 course of treatment. Observe clinical symptoms, abdominal distention, abdominal pain, defecation and adverse reactions. 3 courses of continuous treatment （3 weeks） were used to determine the curative effect. [Results] The treatment group recovered 9 cases, effective 10 cases, effective 9 cases, invalid 2 cases, total effective rate 93.33%, the control group cured 3 cases, 9 cases, effective 10 cases, invalid 8 cases, total effective 73.33%, the treatment group was better than the control group （P〈0.05）. Symptom scores in the two groups were improved （P〈0.01）, and the improvement in the treatment group was better than that in the control group （P〈0.01）. [Conclusion] The treatment of constipation irritable bowel syndrome （Changdao Shire） is satisfactory with no serious adverse reactions. It is worth promoting.