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补肾通痹汤联合西药治疗骨痹(肾阳亏虚寒凝痹阻)随机平行对照研究 被引量:2

Randomized Controlled Study of Bushen Tongbi Decoction(补肾通痹汤) Combined with Western Medicine in Treating(Kidney Yang Deficiency and Cold Coagulation Block/肾阳亏虚寒凝痹阻)Gubi
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摘要 [目的]观察补肾通痹汤联合西药治疗骨痹(肾阳亏虚寒凝痹阻)疗效。[方法]使用随机平行对照方法,将120例住院患者按病历号抽签简单随机分为两组。对照组60例塞来昔布,0.2g/次,2次/d;柳氮磺吡啶,1g/次,2次/d。治疗组60例补肾通痹汤(淫羊藿30g,地黄~熟、山茱萸、杜仲、~川牛膝各15g,地龙1条,骨碎补、川芎、当归、海风藤、桑枝各15g,甘草10g),1剂/d,水煎150mL,早晚口服;西药治疗同对照组。连续治疗10d为1疗程。观测临床症状、中医症候积分、红细胞沉降率(ESR)、超敏C-反应蛋白(hs-CRP)、免疫球蛋白G(IgG)、不良反应。连续治疗3疗程(30d),判定疗效。[结果]治疗组治愈2例,显效16例,有效37例,无效5例,总有效率91.67%;对照组治愈1例,显效14例,有效28例,无效17例,总有效率71.67%;治疗组疗效优于对照组(P<0.01)。中医症候积分两组均有明显降低(P<0.01),治疗组降低优于对照组(P<0.01);ESR、hs-CRP、IgG两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]补肾通痹汤联合西药治疗骨痹(肾阳亏虚寒凝痹阻),疗效满意,无严重不良反应,值得推广。 [Objective] To observe the curative effect of Bushen Tongbi decoction combined with western medicine in treating (Kidney Yang deficiency and cold coagulation block)Gubi. [Method] A randomized parallel control method was used to randomly divide 120 hospitalized patients into two groups according to the medical record number. There were 60 patients in the control group. Celecoxib, 0.2 g/time, 2 times/ d; sulfasalazine, 1 g/time, 2 times/d. There were 60 patients in the treatment group. Bushen Tongyu deeoction(epimedium30g, mature rehmannia glutinosa, cornel, eucommia,achyranthes each 30g, earthworm one, rhizome of drynaria,chuanxiong rhizome, angelica, futokadsura stem, mulberry twigs each 15g, licorice root 10g). 1 dose/d, decoction 150mL, Oral in the morning and evening. Western medicine treatment was the same as the control group. Continuous treatment for 10 days was a course of treatment.The study would observe clinical symptoms, TCM symptom scores, erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hs-CRP), immunoglobulin G (IgG), and adverse reactions. Continuous treatment of 3 courses to determine efficacy. [Result] The treatment group was cured in 2 cases, markedly effective in 16 cases, effective in 37 cases, ineffective in 5 cases, and the total effective rate was 91.67%. The control group was cured in 1 ease, markedly in 14 cases, effective in 28 cases, invalid in 17 cases, and the total effective rate was 71.67%. The therapeutic effect of the treatment group was better than that of the control group (P 〈0.01). TCM symptoms scores were significantly lower in both groups (P〈0.01), treatment group was better than control group (P〈0.01), ESR, hs-CRP, IgG were improved (P〈0.01), treatment group improved In the control group (P〈0.01). [Conclusion] Bushentongyu decoction combined with western medicine treatment of (Kidney Yang deficiency and cold coagulation block) Gubi has satisfactory effect and no serious adverse reactions, it is worth promoting.
作者 王浩 崔立建 周长春 安玉芳 WANG Hao;CUI Lijian;ZHOU Changchtm;AN Yufang(Orthopedics Department of Heilongjiang Medical College of Traditional Chinese Medicine,Harbin 150036,China)
出处 《实用中医内科杂志》 2018年第7期27-30,共4页 Journal of Practical Traditional Chinese Internal Medicine
关键词 强直性脊柱炎 骨痹 肾阳亏虚 寒凝痹阻 补肾通痹汤 塞来昔布 柳氮磺吡啶 中医症候积分 红细胞沉降率(ESR) 超敏C-反应蛋白(hs-CRP) 免疫球蛋白G(IgG) 中药复方 中西医结合治疗 随机平行对照研究 ankylosing spondylitis Gubi Kidney Yang deficiency and cold coagulation block(肾阳亏虚寒凝痹阻) Bushen Tongyu decoction(补肾通痹汤) celecoxib sulfasalazine TCM symptom score erythroeyte sedimentation rate (ESR) hypersensitivity C-Reactive protein (hs-CRP) immunoglobulin G(IgG) Chinese herbal compound Integrated Chinese and western medicine randomized parallel controlled study
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