腮腺恶性肿瘤巨噬细胞浸润的意义

Clinical and Prognostic Significance of Macrophage-infiltration in Parotid Malignant Tumors

50例腮腺恶性肿瘤组织中巨噬细胞浸润数量,与肿瘤大小和面神经侵犯无关,与肿瘤分化程度、淋巴结转移和术后复发密切相关。提示巨噬细胞参与肿瘤局部的免疫反应,其浸润数量可作为估价预后的一项指标。

Fifty paraffin-embedded parotid carcinoma specimens from patients who were followed-up more than 5 years after operation were examined for the infiltration of macrophages (Mφ) by using PAP technique. The number of infiltrating Mφ was quantitated and the result was analyzed in connection with tumor differentiation degree, size, metastasis, invasion to the facial nerves and tumor free interval. In the cancerous histological architecture, the Mφ stretch out cytoplasmic projections which lie in close contact with the tumor cells or suround the tumor cells. Different degrees of tumor destruction were demonstrated in the area infiltrated by the Mφ. The number of Mφ-infiltration in the well differentiated tumor is more than that in the poorly differentiated tumor (P<0.01). The group of malignant tumors without metastasis and with a longer tumor free interval contain more infiltrating Mφ than the group of those with metastasis and recurrence within 5 years (P<0.01). These findings suggest that macrophage plays an important role in local antitumor immunity in parotid malignant tumor.