血清FT3水平与急性脑梗死患者颅内外动脉粥样硬化及狭窄的关系

Relationship between FT3 level and intracranial and extracranial atherosclerotic stenosis in patients with acute cerebral infarction

目的探讨FT3水平与急性脑梗死患者颅内外动脉粥样硬化及狭窄的关系。方法选择急性脑梗死148例为试验组，同期人院非急性脑梗死无脑动脉硬化97例为对照组，比较组间一般临床特征，将P〈0．05各变量纳入回归分析。据动脉硬化部位、程度将试验组分为不同亚组，比较组间FT3水平。结果急性脑梗死患者FT3、TSH水平明显低于对照组（P〈0．05）；Logistic回归分析结果显示，FT3为急性脑梗死的保护性因素（OR=O．060，95％CI=0．019-0．191，P〈0．001）及急性脑梗死动脉硬化的独立保护性因素（OR=0．049，95％C1=0．015。0．157，P〈0．001）。颅内不同动脉硬化部位以及程度、颈动脉不同动脉硬化程度组间比较，差异无统计学意义（尸〉0．05），随着颈动脉狭窄程度越重，FT3水平有下降的趋势。结论急性脑梗死患者FF3水平下降，FT3是急性脑梗死的保护性因素；FT3水平与急性脑梗死颅内狭窄部位、程度以及颈动脉狭窄程度无关。

Objective To explore the relationship between FT3 level and intracranial and extracranial atherosclerotie stenosis in patients with acute cerebral infarction. Methods A total of 148 cases of acute cerebral infarction were selected as the experimental group, and 97 cases of non-acute cerebral infarction admitted in the same period were treated as the control group. The general clinical features of the two groups were compared, and the variables （P 〈 0.05） were included in the regression analysis. According to the location and degree of arteriosclerosis, the experimental group was divided into subgroups to compare the level of FT3. Results The level of FT3 and TSH in patients with acute cerebral infarction was significantly lower than that in the control group （P 〈 0.05）. The result of Logistic regression analysis showed that FT3 was the protective factor of acute cerebral infarction （OR=O.060, 95%CI=0.019-0.191, P〈0.001）, and an independent protective factor for arteriosclerosis in FT3 acute cerebral infarction （OR=0.049, 95%C1=0.015-0.157, P 〈 0.001）. There was no significant difference in the location and degree of intracranial arteriosclerosis and the degree of arteriosclerosis between the carotid arteries （P 〉 0.05）. The level of FV3 showed a decrease trend, as the degree of carotid stenosis increased. Conclusions The level of FT3 in patients with acute cerebral infarction decreases, and FT3 is a protective factor for acute cerebral infarction. The level of FT3 is not related to the location and degree of intracranial stenosis and the degree of carotid artery stenosis in acute cerebral infarction.