甲状腺功能减退性肌病的诊治进展

Progress in diagnosis and treatment of hypothyroid myopathy

临床上，甲状腺功能减退性肌病（HM）并不少见，但有时诊断却比较困难。一般通过仔细询问病史，适当的血液化验来对HM进行临床诊断。虽然肌电图检查没有特异性，但对评估神经肌肉受损程度是有用的。MRI和肌肉活检有助于鉴别诊断。HM预后一般良好，治疗的关键是甲状腺激素替代治疗，治疗的效果也是诊断HM的重要依据。本文从HM的发病机制、临床表现、诊断与鉴别诊断、治疗和预后方面进行综述。

Clinically, hypothyroidism （HM） is not uncommon, but sometimes it is difficult to be diagnosed. Careful medical history and proper blood test are helpful for clinical diagnosis of HM. Although electromyography is not specific, it is useful in assessing the degree of neuromuscular impairment. MRI and muscle biopsy are helpful for differential diagnosis. The prognosis of HM is good. Thyroid hormone replacement therapy is the key treatment. The therapeutic effect is also an important basis for diagnosing HM. This article reviews the pathogenesis, clinical manifestations, diagnosis and differential diagnosis, treatment and prognosis of riM.