男性吸烟者吸烟行为与2型糖尿病关系

Relationship between smoking and type 2 diabetes mellitus among male smokers

目的探讨男性吸烟剂量与2型糖尿病患病的关系。方法 2016年7—12月,在广东省中山市采用多阶段抽样方法抽取6 150名居民进行问卷调查、体格检查和实验室检测,使用logistic回归模型和限制性立方样条模型,分析男性吸烟者的吸烟剂量与2型糖尿病患病的关联性。结果总人群吸烟率为18.24%,男性吸烟率为38.16%;总人群糖尿病患病率为5.48%,男性吸烟者2型糖尿病患病率为6.13%;调整年龄、户籍、婚姻、BMI、受教育水平、家庭月均收入、高血压史等因素后,多因素logistic回归分析显示,现在吸烟者与2型糖尿病患病有关(OR=1.45,95%CI=1.10~1.92;OR调整=1.43,95%CI=1.10~1.90);限制性立方样条模型(RCS)显示,男性吸烟者吸烟数量、吸烟指数与2型糖尿病呈非线性剂量–反应关系(非线性检验,P<0.05)。结论男性吸烟的剂量与2型糖尿病发病有关。

Objective To explore the association of smoking amount with the prevalence of type 2 diabetes mellitus（T2 DM） among male smokers. Methods We conducted a questionnaire survey, physical examination and laboratory tests among 6 150 residents aged 18 – 79 years and recruited with multistage random sampling in Zhongshan city of Guangdongprovince between July and December 2016. We adopted restricted cubic spline model and logistic regression to assess the association of smoking amount with T2 DM among male smokers. Results The smoking rate in the all participants was18.24% and that in the male participants was 38.16%. The prevalence of T2 DM in the all participants 5.48%, and that in the male smokers 6.13%. The results of multivariate logistic regression analysis revealed that that current smoking was a significant risk factor of T2 DM, with the odds ratio [OR] of 1.45（95% confidence interval [95% CI]： 1.10 – 1.92） after adjusting for age, permanent residence address, marital status, body mass index, education, and average household monthly income and the OR of 1.43（95% CI： 1.10 – 1.90） after adjusting for age, permanent residence address, marital status, body mass index, education, average household monthly income, and hypertension history. The restrictive cubic spline（RCS）model analysis indicated a non-linear dose-response correlation of number of cigarette smoked per day and smoking index（number of cigarette smoked per day multiplied by year of smoking） with T2 DM among male smokers（P〈0.05）.Conclusion Smoking amount correlates with the incidence of type 2 diabetes mellitus among male smokers.