用马来酸麦角新碱、卡贝缩宫素及卡前列素氨丁三醇治疗宫缩乏力性产后出血的效果对比

Comparison of the efficacy of ergoxin maleate, cabbetine and carprost in the treatment of uterine weakness postpartum hemorrhage

目的 :对比使用马来酸麦角新碱、卡贝缩宫素及卡前列素氨丁三醇治疗宫缩乏力性产后出血的临床效果。方法 :选择在蓬溪县妇幼保健计划生育服务中心接受治疗的90例宫缩乏力性产后出血产妇作为研究对象。按照使用药物的不同将这90例产妇分为麦角新碱组、卡贝组和卡前列素氨丁三醇组,每组各有30例产妇。为麦角新碱组产妇使用马来酸麦角新碱注射液进行治疗,为卡贝组产妇使用卡贝缩宫素注射液进行治疗,为卡前列素氨丁三醇组产妇使用卡前列素氨丁三醇注射液进行治疗。然后,比较三组产妇产后2 h、24 h其阴道的出血量、心脏收缩压的水平、心脏舒张压的水平、心率、不良反应的发生率及产后的出血率。结果 :治疗后,卡贝组产妇产后2 h、24 h其阴道的出血量、不良反应的发生率、产后的出血率均低于麦角新碱组产妇和卡前列素氨丁三醇组产妇,差异有统计学意义(P<0.05)。三组产妇收缩压的水平、舒张压的水平及心率相比,差异无统计学意义(P>0.05)。结论 :这三种药物均能够有效地治疗宫缩乏力性产后出血,其中,卡贝缩宫素的效果更优。临床医师应根据此病患者的具体情况为其选择合适的缩宫素进行治疗,以减轻药物对其身体的影响。

objective： to compare the clinical effects of the use of ergoxin maleate, carbetine and carprost in the treatment of uterine weakness postpartum hemorrhage. Methods： 90 cases of postpartum haemorrhagic uterine contractions treated at the pengxi maternal and child health and family planning service center were selected as subjects. According to different drugs, the 90 parturients were divided into the ergoxin group, the kappe group and the kappacide group, with 30 parturients in each group. The patients in the ergoxin group were treated with ergoxin maleate injection, the patients in the kappa group were treated with carbamidine injection, and the patients in the kappa group were treated with carprost injection. Then, the vaginal bleeding, systolic blood pressure, diastolic blood pressure, heart rate, incidence of adverse reactions and postpartum bleeding rates were compared between the three groups at 2 h and 24 h after delivery. Results： after the treatment, the vaginal blood loss, incidence of adverse reactions and postpartum bleeding rate in the karbe group at 2 h and 24 h postpartum were all lower than that in the lyserine group and the carprostine triol group, with statistieaUy significant differences （P 〈 0.05）. The differences of systolic blood pressure, diastolic blood pressure and heart rate between the three groups were not statistically significant （P 〉 0.05）. Conclusion： all of these three drugs can effectively treat uterine inertia postpartum hemorrhage, among which eabrerine is more effective. The clinician should select appropriate oxytocin for the treatment according to the specific situation of the patient, so as to reduce the effect of the drug on his or her body.