糖皮质激素联合慢作用抗风湿药治疗类风湿性关节炎的临床效果

Clinical effects of glucocorticoid combined with slow acting antirheumatic drugs on rheumatoid arthritis

目的探讨糖皮质激素联合慢作用抗风湿药对类风湿性关节炎的疗效。方法回顾性分析2015年6月至2017年10月56例类风湿性关节炎患者的临床资料,随机将其分为对照组和观察组,每组28例。对照组患者应用慢作用抗风湿药治疗,观察组患者应用糖皮质激素联合慢作用抗风湿药治疗。比较两组患者的治疗疗效、关节炎指标以及不良反应发生率。结果治疗后,观察组患者的治疗总有效率为92.85%,高于对照组的67.85%(P<0.05);观察组患者关节炎指标优于对照组,不良反应发生率低于对照组,差异均有统计学意义(P<0.05)。结论糖皮质激素联合慢作用抗风湿药治疗类风湿性关节炎患者此临床效果显著,能够改善关节炎指标,降低不良反应发生率,临床应用价值较高。

Objective To investigate the effects of glucocorticoid combined with slow acting antirheumatic drugs on rheumatoid arthritis（ RA）. Methods A total of 56 patients with RA were selected and randomly divided into the control group and the observation group,with 28 patients in each group.The patients in the control group were treated with slow acting antirheumatic drugs,and the patients in the observation group were treated with glucocorticoid combined with slow acting antirheumatic drugs. After treatment,the therapeutic efficacy,arthritis index and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group,and the index of arthritis was better than that of the control group. The incidence of adverse reactions was lower than that of the control group,the differences were significant（ P〈0. 05）. Conclusions In the treatment of patients with rheumatoid arthritis,the clinical effects of glucocorticoid combined with slow acting antirheumatic drugs is significant. It can improve the index of arthritis and reduce the incidence of adverse reactions,which is of high clinical application value.