GnRHa联合坤泰胶囊治疗子宫内膜异位症患者的疗效观察

Efficacy of GnRHa Combined Kuntai Capsule on Endometriosis

[目的]探讨促性腺激素释放激素激动剂（GnRHa）联合坤泰胶囊治疗子宫内膜异位症（简称内异症）患者的临床疗效.[方法]收集2015年4月到2017年2月本院诊治的内异症患者150例,按照随机数表法分为观察组和对照组.对照组采用GnRHa治疗,观察组在对照组基础上加用坤泰胶囊治疗.比较两组患者治疗前后性激素、体液免疫指标、Kupperman评分及骨密度值变化,并评价两组临床疗效及用药安全性.[结果]观察组治疗总有效率为90.67％（68/75）,显著高于对照组的70.67％（53/75）,不良反应发生率为5.33％（4/75）,明显低于对照组的16.00％（12/75）,其差异均有统计学意义（均P〈0.05）;治疗后观察组血清雌二醇（E2）、卵泡刺激素（FSH）、黄体生成素（LH）、补体3（C3）、C4水平显著低于对照组,其差异有统计学意义（P〈0.05）;两组治疗前后血清免疫球蛋白G（IgG）、IgM及骨密度比较差异无统计学意义（P〉0.05）;治疗后观察组Kupperman评分显著低于对照组,其差异有统计学意义（P〈0.05）.[结论]GnRHa联合坤泰胶囊治疗内异症患者疗效确切,能改善性激素水平,提高体液免疫功能,减轻或消除临床症状,且安全性高,值得临床推广应用.

[Objective] To evaluate the effect of gonadotropin releasing hormone agonist （GnRHa） com- bined with kuntai capsule on the sex hormone and humoral immunity of endometriosis patients. [Methods] A total of 150 patients with endometriosis in our hospital from April 2015 to February 2017 were selected and randomly divided into two groups： the control group （75 cases） and the observation group （75 cases）. The control group was treated with GnRHa, and the observation group was treated with Kuntai capsule on the basis of the control group. The changes of sex hormones, humoral immunity index, Kupperman score and bone mineral density before and after treatment were compared between the two groups, and the clinical efficacy and medication safety of the two groups were evaluated.[Results] The total effective rate of the observation group was 90.67 % （68/75）, which was significantly higher than that of the control group 70.67 % （53/75）. The ad- verse reaction rate of the observation group was 5.33%（4/75） ,which was lower than that of the control group of 16.00% （12/75）. The difference was statistically significant （ P 〈0.05）. After treatment, the levels of ser- um estradiol （E2）, follicle stimulating hormone （FSH）, luteinizing hormone （LH）, complement 3 and 4 （C3 and C4） in the observation group were lower than those in the control group; the difference were statistically significant （ P〈0.05）. There were no statistically significant differences in serum immunoglobulin G （IgG）, IgM and bone density between the two groups before and after treatment （ P -0.05）. After treatment, the C4 levels and complement were lower than those in the control group, and the difference was statistically significant （ P〈0.05）. After treatment, the Kupperman score in the observation group was lower than that in the control group; and the differences were statistically significant （ P〈0.05）. [Conclusion] The treatment of GnRHa combined Kuntai capsule for endometriosis patients has better curative effect. It can adjust body sex hormone levels, improve humoral immune function, and alleviate or eliminate clinical symptoms with medication safety.