血清Cys-C、HCY及BTP与妊娠期高血压患者病情程度的相关性研究

Correlation of Serum Cys-C, HCY and BTP Levels with Severity in Patients with Pregnancy-Induced Hypertension

[目的]探讨血清胱抑素-C（Cys-C）、同型半胱氨酸（HCY）及β-痕迹蛋白（BTP）与妊娠期高血压疾病患者病情程度的相关性.[方法]选择2013年7月至2017年6月在本院诊治的82例妊娠期高血压疾病患者作为观察组（A组）,按照不同的病情程度分为三个亚组：妊娠期高血压组（29例,A1组）、子痫前期轻度组（28例,A2组）和子痫前期重度组（25例,A3组）.以同期在本院住院的健康妊娠妇女82例为对照组（B组）,分别检测以上各组受试对象血清Cys-C、HCY及BTP水平,分析Cys-C、HCY及BTP水平与患者病情程度相关性.[结果]A组血清Cys-C、HCY及BTP的水平均高于B组相对应的血清水平（P〈0.05）,A3组血清Cys-C、HCY及BTP的水平高于A2组和A1组相对应的血清水平（P〈0.05）,A2组血清Cys-C、HCY及BTP的水平高于A1组相对应的血清水平（P〈0.05）;血清Cys-C、HCY及BTP水平与妊娠期高血压疾病患病程呈现明显正相关关系（P〈0.05）.[结论]血清Cys-C、HCY及BTP水平与妊娠期高血压疾病病情程度呈明显正相关,并且随着病情程度的加重而升高明显,检测血清中三项指标有助于指导妊娠期高血压疾病临床诊治.

[Objective]To explore the correlation of serum cystatin-C （Cys-C）, homocysteine （HCY） and beta-trace protein （BTP） levels with the severity in patients with pregnancy-induced hypertension. [Methods] A total of 82 patients with diagnosis of pregnancy-induced hypertension disease from July 2013 to June 2017 in our hospital were selected as the observation group （group A）. According to the severity of the disease, pa- tients were divided into three subgroups： 29 cases of gestational hypertension group （A1）, 28 cases of mild preeclampsia group （A2）, and 25 cases of severe preeclampsia group （A3）. In the same period, 82 healthy pregnant women admitted in our hospital were enrolled as the control group （group B）. The levels of serum Cys-C, HCY and BTP, were detected in patients of all groups. The severity of pregnancy-induced hypertension in correlation with the levels of Cys-C, HCY and BTP were analyzed . [Results]The levels of serum Cys-C, HCY and BTP in the observation group （A） were higher than those of control group （B） （ P -0.05）. The levels of serum Cys-C, HCY and BTP in the severe preeclampsia group （A3） were higher than those of mild preeclampsia group （A2） and gestational hypertension group （A1）. The levels of group A2 were higher than those of group A1 （ P 〈0.05）. Furthermore, the serum levels of Cys-C, HCY and BTP were significantly positively correlated with the severity of pregnancy-induced hypertension. [Conclusion] The levels of serum Cys-C, HCY and BTP positively reflected the severity of pregnancy-induced hypertension. Detection of these three serum indicators can help the clinical diagnosis and treatment of pregnancy-induced hypertension.