摘要
血红素加氧酶（heme oxygenase,HO）-1是最具生物活性的HO类型,在缺血再灌注损伤时通过发挥抗氧化、抗炎和细胞保护作用减轻组织损伤,被认为是治疗缺血再灌注损伤的新方向.文章对HO-1在缺血再灌注损伤中的作用及其可能机制进行了综述.
Heme oxygenase （HO） -1 is the most bioactive HO type. It reduces tissue damage by exerting antioxidant, anti-inflammatory, and cytoprotective effects during ischemia-reperfusion injury. It is considered to be a new direction for the treatment of ischemia-reperfusion injury. This article reviews the role of HO-1 in ischemia-reperfusion injury and its possible mechanisms.
作者
邱文娟
王建红
郭富强
Qiu Wenjuan, Wang Jianhong, Guo Fuqiang(Clinical Medical College of Southwest Medical University, Luzhou 646000, China ; Department of Neurology, Sichuan Provincial People＇s Hospital, Sichuan Academy Medical Sciences, Chengdu 610072, China)
出处
《国际脑血管病杂志》
2018年第6期464-467,共4页
International Journal of Cerebrovascular Diseases
关键词
脑缺血
再灌注损伤
血红素加氧酶-1
炎症
氧化应激
细胞凋亡
新生血管化
生理
性
信号转导
神经保护药
Brain Ischemia
Reperfusion Injury
Heme Oxygenase-1
Inflammation
Oxidative Stress
Apoptosis
Neovascularization
Physiologic
Signal Transduction
Neuroprotective Agents
