DNA甲基化与动脉粥样硬化

DNA methylation and atherosclerosis

动脉粥样硬化是环境与遗传因素相互作用导致的全身慢性炎性疾病.表观遗传修饰是连接环境因素与遗传因素的桥梁,DNA甲基化是一种重要的表观遗传修饰调控方式,可在转录前水平调节基因表达.已有研究表明,DNA甲基化在动脉粥样硬化的发生和发展过程中发挥着重要作用.因此,可通过天然或合成的DNA去甲基化酶使动脉粥样硬化相关DNA去甲基化,尤其是颈动脉粥样硬化相关DNA去甲基化,从而达到预防或治疗动脉粥样硬化性脑血管病的目的 .文章围绕DNA甲基化及其与动脉粥样硬化的关系以及DNA去甲基化治疗进行了综述.

Atherosclerosis is a chronic systemic inflammatory disease caused by the interaction of environment and genetic factors. Epigenetic modification is a bridge between environmental factors and genetic factors. DNA methylation is an important regulatory mode of epigenetic modification, which can regulate gene expression at the pre-transcriptional level. Studies have shown that DNA methylation plays an important role in the occurrence and development process of atherosclerosis. Therefore, atherosclerosis-related DNA demethylation, especially carotid atherosclerosis-related DNA demethylation, can be achieved by natural or synthetic DNA demethylases, thereby achieving the purpose of preventing or treating atherosclerotic cerebrovascular disease. This article reviews DNA methylation and its relationship with atherosclerosis and DNA demethylation therapy.