微创置管吸引术对脑出血患者hs-CRP、TNF-α、IL-8及MEP水平的影响

Influence of minimally invasive catheterization on the levels of hs-CRP, TNF-α, IL-8 and MEP of patients with intracerebral hemorrhage

目的 研究微创置管吸引术（MITS）对脑出血患者超敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-8（IL-8）以及运动诱发电位（MEP）水平的影响.方法 选择2015年3月至2017年1月医院进行治疗的128例脑出血患者,采用数字随机法分为观察组和对照组,每组64例.对照组给予常规的治疗方法,观察组给予MITS治疗,分别比较两组患者的治疗效果,hs-CRP、TNF-α、IL-8、MEP水平,数字评分法（NRS）及口述评分法（VRS）评分.结果 观察组治疗后优良率（98.44％）高于对照组（87.50％）,差异有统计学意义（P〈0.05）;观察组不良反应发生率（6.25％）低于对照组（18.75％）,差异有统计学意义（P〈0.05）;观察组治疗后VAS评分、NRS评分,hs-CRP、TNF-α、IL-8及MEP水平均低于对照组,差异有统计学意义（P〈0.05）.结论 脑出血患者行MITS治疗可有效改善患者的治疗效果,降低不良反应发生率、VAS评分、NRS评分,hs-CRP、TNF-α、IL-8及MEP水平,值得临床推广.

Objective To study the influence of minimally invasive catheterization on the levels of hs-CRP, TNF-ot, IL-8 and MEP of patients with intracerebral hemorrhage. Methods A total of 128 patients with intracerebral hemorrhage treated in hospital from March 2015 to January 2017 were selected. The patients were randomly divided into observation group and control group, with 64 patients in each group. The patients in control group were given routine treatment and patients in observation group were treated with MITS. The therapeutic effects, the levels of hs-CRP, TNF-α, IL-8 and MEP, the scores of VRS and NRS were compared between the two groups after treatment. Results The excellent and good rate of treatment in observation group （98.44%） was higher than that in control group （87.50%）, the difference was significant （ P 〈 0. 05 ）. The incidence of adverse reactions in observation group was 6.25 %, and which was lower than that in the control group （ 18.75 % ）, the difference was significant （P 〈 0. 05）. The VAS scores, NRS scores, the levels of hs-CRP, TNF-α, IL-8 and MEP in observation group after treatment were all lower than those in control group, the differences were significant （ P 〈 0. 05）. Conclusions MITS can effectively improve the therapeutic effect of ICH, reduce the incidence of adverse reactions and VAS score, NRS score, the levels of hs-CRP, TNF-α, IL-8 and MEP, so it is worth popularizing in clinic.