中心组合设计法优化金属MOF材料NP-101对盐酸阿霉素的包合工艺

Optimization of the Inclusion Technology of Doxorubicin Hydrochloride by the MOFs (NP-101) with Central-Composite Design

目的优化新型金属骨架(metal-organic frameworks,MOFs)材料NP-101对盐酸阿霉素的包合工艺。方法以中心组合设计为原理,以药物与载体的投料比、水相p H和超声时间3个主要因素为自变量,以金属骨架材料对盐酸阿霉素的包封率为因变量,利用Design Expert8软件进行数据分析。结果确定了新型金属骨架材料对盐酸阿霉素的最佳包合工艺,工艺参数为药物与载体的比例为1.5,水相p H为7.17,超声时间为25 min,在此条件下包封率为98.3%。结论该方法能够较好地优化金属MOFs材料NP-101对盐酸阿霉素的包合工艺。

OBJECTIVE The optimization of drug loading method of metal-organic frameworks（ MOFs） materials NP-101 for loading doxorubicin hydrochloride. METHODS This study was based on the principle of Central-Composite design. The three main factors,such as feeding ratio,water phase p H and ultrasonic time,were independent variables. The loading rate of MOFs NP-101 for doxorubicin hydrochloride was dependent variable. The data were analyzed by using Design Expert8 software. RESULTS The optimal drug loading method of MOFs NP-101 for loading doxorubicin hydrochloride was determined. The ratio of drug and carrier was 1.5. The p H of water phase was 7.17 and the ultrasonic time was 25 min. Under the above condition,the optimal encapsulation rate was 98.3%.CONCLUSION The drug loading method of this study could well optimize the encapsulation efficiency of MOFs NP-101 for loading doxorubicin hydrochloride.