肿瘤坏死因子α-308基因多态性与非霍奇金淋巴瘤易感性的Meta分析

Tumor necrosis factor-a-308 polymorphism and risk of non-Hodgkin lymphoma： a meta-analysis

目的 探讨肿瘤坏死因子α（TNF-α）-308G＞A基因多态性与非霍奇金淋巴瘤（NHL）易感性的关系.方法 在PubMed、中国知网、万方数据知识服务平台等数据库,检索淋巴瘤（或lymphoma）和肿瘤坏死因子（tumor necrosis factor或TNF）、基因多态性（polymorphism或SNP或variant或mutation）,获取相关文献,采用固定效应模型或随机效应模型进行数据合并统计.发表偏移的评估采用Begg漏斗图和Egger检验.结果 共纳入15篇文献,包含9 738例NHL患者和10 854例对照人群.对入选文献数据进行综合分析,纯合子基因模型（AA比GG：OR=1.55,95％CI 1.30 ～ 1.86,I^2=42.4％）和隐性基因模型（AA比AG＋GG：OR=1.53,95％CI 1.27～1.83,I^2=41.8％）的统计结果显示,TNF-α-308 AA基因可能增加NHL的发病风险.按种族来源不同进行分层分析,结果表明A等位基因可增加高加索人群罹患NHL的风险（A比G、AA比GG、AG比GG、AA比AG＋GG、AA＋AG比GG）,但可降低亚裔人群的发病风险（A比G、AG比GG、AA＋AG比GG）.结论 TNF-α-308 G＞A基因多态性与NHL的发病风险相关.

Objective To investigate the association between the tumor necrosis factor （TNF）-α-308 G〉A polymorphism and risk of non-Hodgkin lymphoma （NHL）.Methods PubMed,CNKI and Wanfang dataknowledge service platform were searched to obtain relevant literature by using the following terms：lymphoma and （tumor necrosis factor or TNF） and （polymorphism or SNP or variant or mutation）.Overall results were combined by using fixed effect model or random effect model.Publication bias was evaluated by using the Begg funnel plot and Egger test.Results Fifteen eligible studies were identified,including 9 738 NHL cases and 10 854 controls.The results of the overall meta-analysis showed that the TNF-α-308 AA genotype was associated with increased risk of NHL in two genetic models （AA vs.GG：OR =1.55,95 % CI 1.30-1.86,I^2 =42.4 %;AA vs.AG＋GG：OR =1.53,95 % CI 1.27-1.83,I^2 =41.8%）.Stratified by ethnicity,TNF-α-308 A allele was associated with an increased NHL risk in Caucasians （A vs.G;AA vs.GG;AG vs.GG;AA vs.AG＋GG;AA＋AG vs.GG） but a decreased risk in Asians （A vs.G;AG vs.GG;AA＋AG vs.GG）.Conclusion The TNF-o-308 G〉A polymorphism is associated with the risk of NHL.