自噬在慢性粒细胞白血病治疗中的研究进展

Progress of autophagy in treatment of chronic myelogenous leukemia

自噬在癌症、神经变性、自身免疫疾病和炎症疾病的发生、发展和治疗中扮演重要角色.近些年,自噬成为肿瘤研究领域的新热点.慢性粒细胞白血病（CML）是一种常见的血液系统肿瘤,自噬参与了其发展以及靶向药物酪氨酸激酶抑制剂耐药机制,通过调节自噬为CML的治疗提供了新方向.细胞自噬和癌症的深入研究会有助于攻克癌症.文章对自噬在CML治疗中相关研究进展作一综述.

Autophagy plays an important role in the occurrence,progression and treatment of cancer,neurodegenerative,autoimmune and inflammatory diseases.Recent years,autophagy has become a new hot spot in tumor area.Chronic myelogenous leukemia （CML） is a common hematopoietic malignancy;while autophagy is involved in its development,as well as targeting drug tyrosine kinase inhibitor resistance mechanisms,regulating autophagy provide a new direction for the treatment of CML.The intensive study of the relation between cell autophagy and cancer will help to overcome cancer.This article offers an up-to-date comprehensive review of autophagy and CML.