早产儿代谢性骨病研究进展

Research progress on metabolic bone disease of prematurity

早产儿代谢性骨病,是指由于体内钙磷代谢紊乱所致的骨矿物质含量的异常,导致骨小梁数量减少、骨皮质变薄等骨骼改变。该病早期缺乏典型的临床症状或者敏感且特异的检查指标,后期确诊已出现严重并发症,如出现佝偻病或病理性骨折。所以早期发现、明确诊断和有效治疗亟待解决。本文主要就有关早产儿代谢性骨病的临床表现、诊断、治疗及预防措施进行综述。

Metabolic bone disease（MBD）of prematurity is defined as disorder of diminished bone mineralization,leading to bone changes,decrease of bone trabecular and cortex of bone.There are no typical clinical symptoms or sensitive and specific examination indicators in the early stage of the disease.While serious complications have occurred in later diagnosis,such as rickets or pathological fracture.So it is important to discover,diagnose and treat early.This paper focuses on the publications in recent years to summarize the background,influencing factors,clinical manifestation,diagnosis,treatment and prevention measures of MBD.