血管内介入与尤瑞克林联合疗法对急性脑梗死患者HCY和ENOS水平的影响

The effect of intravascular intervention and urinary kallidinogenase combined therapy on the HCY and ENOS levels in patients with acute cerebral infarction

目的:探讨血管内介入与尤瑞克林联合疗法对急性脑梗死(ACI)患者同型半胱氨酸(HCY)、内皮型一氧化氮合成酶(ENOS)水平的影响。方法:选取2015-01—2018-01期间我院收治的ACI患者120例,依据随机数字表法分为介尤组(60例)和常规组(60例),常规组给予对症和血管内介入治疗,介尤组在此基础上给予尤瑞克林治疗,比较2组HCY、ENOS、脑血流[脑血管血流速度(V)、血流量(Q)、外周阻力(R)]、美国国立卫生研究院卒中量表(NIHSS)评分、治疗疗效和安全性。结果:介尤组和常规组治疗后HCY、R、NIHSS评分明显低于治疗前,介尤组治疗后HCY、R、NIHSS评分明显低于常规组,介尤组和常规组治疗后ENOS、V、Q明显高于治疗前,介尤组治疗后ENOS、V、Q明显高于常规组,差异均有统计学意义(均P<0.05);介尤组治疗有效率明显高于常规组,差异有统计学意义(P<0.05);介尤组和常规组脑出血率比较,差异无统计学意义(P>0.05),2组均无死亡发生。结论:血管内介入与尤瑞克林联合疗法可有效改善ACI患者HCY、ENOS水平和脑血流,有利于促进患者神经功能恢复而提高治疗疗效,且具有良好的安全性,值得临床作进一步推广。

Objective：To discuss the effect of intravascular intervention and urinary kallidinogenase combined therapy on the homocysteine（HCY）,endothelial nitric oxide synthetase（ENOS）levels in patients with acute cerebral infarction（ACI）.Method：One hundred and twenty patients with ACI from January 2015 to January 2018 in our Hospital were selected,and divided into urinary intravascular group and routine group according to the random number table,60 cases each group.Routine group was given symptomatic and intravascular interventional therapy,and urinary intravascular group was given urinary kallidinogenase therapy on this basis.The level of HCY,ENOS,cerebral blood flow[cerebral blood flow velocity（V）,blood flow（Q）,peripheral vascular resistance（R）],scores of National Institutes of Health Stroke Scale（NIHSS）,therapeutic efficacy and safety were compared between the two groups.Result：The HCY,R levels and NIHSS scores after treatment were significantly lower than those before treatment in both groups,and were significantly lower in the urinary intravascular group than those in the routine group.The ENOS level,V,Q after treatment were significantly higher than those before treatment in both groups,and were significantly higher in the urinary intravascular group than those in the routine group（P〈0.05）.The therapeutic efficacy in the urinary intravascular group was significantly higher than that in the routine group（P〈0.05）.The cerebral hemorrhage incidence between the two groups was no statistically significant（P〉0.05）,and there was no death in both groups.Conclusion：The intravascular intervention and urinary kallidinogenase combined therapy can effectively improve the HCY,ENOS levels and cerebral blood flow in patients with ACI.It is beneficial to promote the recovery of nerve function and improve the therapeutic effect,and it has good safety.It＇s worth further clinical promotion.