匹多莫徳联合维生素A、E对反复呼吸道感染儿童免疫功能及临床疗效的影响

Effect of pidotiol combined with vitamin a and e on immune function and clinical efficacy of children with recurrent respiratory tract infection

目的:探讨匹多莫徳联合维生素A、E对反复呼吸道感染儿童免疫功能及临床疗效的影响。方法:选择2015年1月—2017年1月收治的反复呼吸道感染患儿100例,按随机数字表法分为对照组和观察组,每组50例。对照组患儿给予单纯匹多莫德治疗,观察组患儿给予匹多莫德联合维生素A、E治疗,比较两组患儿免疫功能变化及临床疗效。结果:治疗后,观察组外周血CD4^+T、CD8+T细胞水平显著高于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,观察组Ig A、Ig G水平显著高于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,观察组维生素A、E水平显著高于对照组,两组比较差异有统计学意义(P<0.05)。观察组治疗总有效率为88.00%,显著高于对照组的68.00%,两组比较差异有统计学意义(P<0.05)。结论:匹多莫德联合维生素A、E治疗儿童反复呼吸道感染,能够有效促进患儿免疫功能的提高,疗效显著。

Objective： To investigate the effect and immune function of pidotimod combined with vitamin A and E on children with recurrent respiratory tract infection.Methods： All 100 children with recurrent respiratory tract infection were selected and randomly divided into control group and observation group,50 cases in each group.The control group was treated with only pidotimod.The observation group was treated with pidotimod combined vitamin A and E.The changes of immune function and clinical efficacy of the two groups were compared.Results： After treatment,the level of CD4^＋T、CD8^＋T cells in the peripheral blood of the observation group was significantly higher than that of the control group,the difference was statistically significant（ P〈0.05）.After treatment,the level of Ig A and Ig G in the observation group was significantly higher than that in the control group,and the difference was statistically significant（ P〈0.05）.After treatment,the levels of vitamin A and E in the observation group were significantly higher than those in the control group,and the difference was statistically significant（ P〈0.05）.The total effective rate of treatment in the observation group was 88.00%,which was significantly higher than that of the control group（ 68.00%）,and the difference was statistically significant（ P〈0.05）.Conclusion： Pidotimod combined with vitamin A and E can effectively promote the immune function and curative effect of children with recurrent respiratory tract infection.