桂皮醛对酒精性胃粘膜损伤的防治研究进展

Research progress of cinnamaldehyde on the prevention and treatment of alcoholic gastric mucosa injury

随着饮酒文化的盛行,我国因酒精摄入过量引起的胃肠道出血以及胃炎的发病率呈现逐年上升趋势。临床上用于预防胃粘膜损伤的药物主要以盐酸雷尼替丁为代表,但对肝肾功能有较大损伤。桂皮醛(CA)是中国传统中药材桂枝或肉桂挥发油的主要成分。药理实验证明,桂皮热水提取物的抗溃疡作用较为明显,其有效成分可以用于胃溃疡的治疗,此外桂皮醛还具有镇痛解痉、抗菌、升高白细胞、抗血小板聚集、抗肿瘤、促进血液循环等作用,且毒副作用低。本文从桂皮醛的结构、主要功能、功效及对酒精性胃粘膜损伤的治疗效应展开综述。

[Abstract] With the prevalence of drinking culture, the incidence of gastrointestinal bleeding and gastritis caused by excessive alcohol consumption in China is increasing year by year. Clinically, the drugs used to prevent gastric mucosal injury are mainly represented by ranitidine hydrochloride, but there is significant damage to liver and kidney function. Cinnamic aldehyde （cinnamon aldehyde, CA） is a main component of traditional Chinese herbal medicine cassia twig or cinnamon essential oil. Pharmacological experiments have proved that cinnamon hot water extract has obvious antiuleer effect, so its effective ingredients can be used for the treatment of gastric ulcer. Cinnamic aldehyde also has effect of analgesia, antispastie, antibacterial, and anti-tumor. It can also elevate white blood cell, prevent platelet from aggregating, and promotting blood circulation, with slight effect. This article reviews the structure, main functions and effects of einnamic aldehyde and its therapeutic effect on alcoholic gastric mucosa injury.