骨形态发生蛋白-4与人类生殖的研究

Bone morphogenetic protein-4 and human reproduction

骨形态发生蛋白4(bone morphogenetic protein 4)是BMP家族的一员。1963年,美国的Marshall R.Urist从脱钙的骨基质提取物中首次分离出BMPs。骨形态发生蛋白能够同胚胎骨骼共同发生作用,从而形成蛋白质,能够在骨形成的多个阶段中产生作用,可贯穿全过程。除此之外,尤其是对中枢神经系统的发生。骨形态发生蛋白最终使骨细胞形成钙化骨组织,因此它被人们称为骨形态发生蛋白[1]。近年来随着研究的进一步深入,结果发现BMP4能调控人睾丸Sertoli细胞和卵巢的生理学功能,而且对于胚胎发育也至关重要。综上所述,BMP-4与人类的生殖能力息息相关,随着生殖医学的快速发展,对于生殖方面而言,BMP-4的研究价值更加受到重视,本文作者对此方面的相关研究进展作一综述。

Bone morphogenetic protein 4 is a member of the BMP family. In 1963, Marshall r. Urist of the United States sepa rated the BMPs from the calcium extracellular matrix extract for the first time. BMP to proteins associated with embryonic bone formation, bone formation in all play a role in most of the stage, the morphogenesis in the early stages of beginning, until after birth. It also plays a key role in the central nervous system. Bone morphogenetic protein eventually causes the bone cells to form calcified bone tissue, so it is called. In recent years, with the further research, it has been found that bmp 4 can reg ulate the physiological functions of human testicular Sertoli cells and ovaries, and is also crucial for embryonic development. A hove all, BMP 4 is closely related to the human reproductive capacity, with the rapid development of reproductive medicine, BMP 4 in reproductive research value is becoming more and more attention and pay attention to, are in BMP 4 related research progress on human reproduction.