生物活性肽制备工艺的研究进展

The Research Progress of Preparation of Bioactive Peptide

生物活性肽是一类分子量介于50~10 000 Da,结构介于氨基酸和蛋白质之间的分子聚合物。经试验验证,生物活性肽的功能有抗氧化、抗菌、抗病毒、抗癌、降血压、降胆固醇、神经调节、免疫调节等,有些功能仍在不断被发现和证实中。常见的生物活性肽的制备方法有提取法、合成法、蛋白降解法。阐述了功能性生物活性肽的制备方法,并结合骨肽重点介绍发酵法制备生物活性肽,根据文献报道研究分析并阐述了发酵法制备活性肽的应用前景及未来的研发方向。

The biological active peptide is a kind of molecular weight polymer which molecular weight between 50-10 000 Da,which the molecular structure between amino acids and protein. The proved functions of biological active peptide are anti-oxidation, antibacterial, antiviral, anticancer, fall blood pressure, cholesterol, neuromodulation, immune regulation, etc.Some functions continue to be found and proved still. Preparation methods of bioactive peptides are extraction,synthesis and protein degradation. The article expounded the methods for preparation of functional biological active peptide and talked about fermentation combined with bone peptide,according to the literature analysis and expounds the application of the fermentation of preparation of active peptide prospects and research direction in the future.