乳腺癌超声造影血流动力学参数与VEGF、Flk^(-1)/KDR表达相关性研究

Breast Cancer Ultrasound Hemodynamic Parameters and VEGF, Flk^(-1)/KDR Expression

目的探讨乳腺癌超声造影血流动力学参数与VEGF、Flk^(-1)/KDR表达的相关性。方法选取我院自2012年12月-2014年12月收治的95例乳腺异常患者和25例乳腺正常志愿者,分为正常组、单纯增生组、非典型增生组、导管内原位癌组、浸润性导管癌组,测定血管密度(MVD)及VEGF、Flk^(-1)/KDR的表达情况。结果各组峰值强度、曲线下面积及廓清时间有显著性差异(P<0.001)。各组MVD值分别为(18±5)、(20±5)、(30±4)、(31±8、53±4),有显著性差异(P<0.001)。随着患者病情加重,乳腺M V D也不断升高;VEGF、Flk^(-1)/KDR值从正常组到浸润性导管癌组不断升高,有显著性差异(P<0.001)。结论乳腺癌进展过程中伴随心血管形成及VEGF、Flk^(-1)/KDR受体表达,超声造影通过监测血管密度,可为VEGF、Flk^(-1)/KDR受体表达情况提供参考。

Objective To explore the correlation of contrast-enhanced ultrasound of breast cancer hemodynamic parameters and VEGF, Flk^-1/KDR expression. Methods 95 cases of abnormal breast patients and 25 normal breast volunteers in our hospital were selected from December 2012 to December 2014. They were divided into normal group, simple hyperplasia group, atypical hyperplasia group, intraductal carcinoma in situ and invasive ductal carcinoma group. The expression of MVD and VEGF and Flk^-1/KDR were measured. Results There were significant differences in peak intensity, area under the curve and clearance time in each group （P〈0.001）. The MVD values of each group were （18±5）, （20±5）, （30±4）, （31±8）, （53±4）, there was significant difference between different group （P〈0.001）. As the patient＇s condition worsened, the MVD of the breast increased, and the value of VEGF and Flk^-1/KDR increased from the normal group to the invasive ductal carcinoma group, and there was a significant difference （P〈0.001）. Conclusion The progression of breast cancer is associated with cardiovascular formation and expression of VEGF and Flk^-1/KDR receptors. By monitoring the density of blood vessels, contrast-enhanced ultrasound can provide reference for the expression of VEGF and Flk^-1/KDR receptors.